ArticleClinical interventions in aging2026
Individualized Dynamic Assessment of Mean Arterial Pressure in Hospitalized Older Patients with Acute Kidney Injury: A Retrospective Cohort Study.
Article in Clinical interventions in aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Acute kidney injury (AKI) carries a high burden in hospitalized older adults. While mean arterial pressure (MAP) is a key modifiable factor, the prognostic value of its dynamic, individualized assessment beyond static thresholds remains poorly defined in this population. Patients and Methods: In this retrospective cohort of 1248 hospitalized patients aged ≥65 years with AKI, we proposed and validated a three-dimensional hemodynamic assessment framework, evaluating: (1) the absolute MAP value at AKI onset (MAP Results: Both MAP Conclusion: This study suggests that a dynamic, individualized MAP assessment might refine risk stratification beyond static thresholds in hospitalized older adults with AKI. Internal evaluation of the integrated dynamic phenotype showed improved predictive performance for adverse outcomes. However, given the retrospective design and substantial potential for confounding, these findings are exploratory. They require rigorous external validation in prospective cohorts before any consideration for clinical application.
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