Evidence map›Paper›PMID 42741667›Full record

ArticleJBMR plus2026

Skeletal and body composition effects of orchiectomy in a colony of diet-induced obese cynomolgus macaques.

Melissa A Kirigiti, Lindsay Bader, Cicely Zaro, Casey M McGuire, Jesper J Hansen, Berit O Christoffersen, Ellen M Straarup, Paul Kievit, Kristin A Sauter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JBMR plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Melissa A KirigitiDivision of Metabolic Health and Disease, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, United States.
Lindsay BaderDivision of Metabolic Health and Disease, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, United States.
Cicely ZaroDivision of Metabolic Health and Disease, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, United States.
Casey M McGuireDivision of Metabolic Health and Disease, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, United States.
Jesper J HansenObesity Pharmacology, Obesity Novo Nordisk A/S, Måløv, Denmark.
Berit O ChristoffersenObesity Pharmacology, Obesity Novo Nordisk A/S, Måløv, Denmark.
Ellen M StraarupObesity Pharmacology, Obesity Novo Nordisk A/S, Måløv, Denmark.
Paul KievitDivision of Metabolic Health and Disease, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, United States.
Kristin A SauterDivision of Metabolic Health and Disease, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, United States.ORCID https://orcid.org/0000-0002-8721-3222

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
NIH HHS P51 OD011092
6 · The paper itself

Abstract

Obesity is a leading cause of secondary hypogonadism or low testosterone. Conversely, hypogonadism frequently leads to excess body fat/obesity demonstrating a potentially reciprocal relationship between the two. This study describes the impact of bilateral orchiectomy (ORX) in a colony of diet-induced obese (DIO) male Mauritius cynomolgus macaques (DIO-CM) maintained on a Western Style Diet (WSD). Body composition analysis via DXA was performed prior and up to 15 m postsurgery to determine the long-term changes in hypogonadism. As expected, ORX significantly reduced testosterone, inhibin B, and estrogen while increasing follicle-stimulating hormone and luteinizing hormone throughout the entire follow-up period. Animals lost significant body weight mainly due to a loss of lean but not fat mass. Orchiectomy had detrimental and long-lasting, 15 m postsurgery, effects on bone, including decreased total BMC and BMD, with the most drastic losses localized to the pelvic region. Additionally, animals demonstrated a transient elevation of numerous bone turnover markers. This model demonstrates that in a phenotypically well-characterized colony of DIO-CM, hypogonadism induces lean mass loss, increased body fat percentage, and numerous hallmarks of osteoporosis. This nonhuman primate model is relevant to human bone biology, age-related body composition changes, such as sarcopenic obesity, and hypogonadism and therefore could be utilized to test muscle and bone mass preserving interventions in the future.

Indexed as

cynomolgus macaqueshypogonadismobesityosteoporosissarcopenia

Identifiers

PMID42741667
PMCPMC13573582

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.