ArticleERJ open research2026
Creatine supplementation and respiratory muscle function in health and disease: translational insights from human to mouse.
Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Respiratory muscle weakness contributes to exercise intolerance in both ageing and disease; however current treatment options remain limited. In this study, we investigated the potential for creatine (Cr) supplementation to increase inspiratory muscle strength (PImax) in health and mitigate diaphragm dysfunction in disease. Methods: Using a translational approach, we combined a human inspiratory muscle training (IMT) intervention with a mechanistic preclinical heart failure (HF) model. 29 healthy males (forced expiratory volume in 1 s >80% pred) completed 4 weeks of IMT (30 breaths, twice daily, at 50% PImax), either alone (IMT, n=15) or with Cr (IMT+Cr, n=14). PImax and expiratory muscle strength (PEmax) were assessed pre- and post-IMT. Subsequently, isolated diaphragm fibre bundles from healthy and HF mice underwent Results: In humans, baseline PImax was similar between groups (p=0.554). The 33% increase in PImax after IMT+Cr was greater than the 18% increase after IMT (condition×time interaction; p=0.031). In mice, Cr had no effect in health but increased diaphragm function in HF with improvements in specific force, twitch relaxation, and fatigue resistance (all p<0.05). Conclusion: Cr supplementation was associated with a greater increase in PImax following IMT in healthy adults and improved diaphragm contractile performance in a preclinical model of HF. These findings provide biological plausibility for a potential effect of Cr on intrinsic diaphragm function and warrant confirmation in adequately powered, randomised controlled trials.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.