Evidence map›Paper›PMID 42741579›Full record

ReviewEuropean cardiology2026

Floppy Mitral Valve/Mitral Valve Prolapse: Diagnosis and Clinical Classification in This Continuing Odyssey.

Konstantinos Dean Boudoulas, Filippos Triposkiadis, Konstantinos Marmagkiolis, Cezar Iliescu, Mehmet Cilingiroglu, Antonios Pitsis, Christodoulos Stefanadis, Harisios Boudoulas

Abstract readReview
In one paragraph

Review in European cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Konstantinos Dean BoudoulasDivision of Cardiovascular Medicine, Ohio State University Columbus, OH, US.
Filippos TriposkiadisDepartment of Cardiology, Larissa University General Hospital Larissa, Greece.
Konstantinos MarmagkiolisTampa Heart Tampa, FL, US.
Cezar IliescuDepartment of Cardiology, University of Texas MD Anderson Cancer Center Houston, TX, US.
Mehmet CilingirogluDepartment of Cardiology, University of Texas MD Anderson Cancer Center Houston, TX, US.
Antonios PitsisCardiac Surgery Institute of Thessaloniki Thessaloniki, Greece.
Christodoulos StefanadisUniversity of Athens Medical School Athens, Greece.
Harisios BoudoulasDivision of Cardiovascular Medicine, Ohio State University Columbus, OH, US.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Few disorders have evoked more interest and controversy in cardiology over recent centuries than floppy mitral valve (FMV)/mitral valve prolapse (MVP). FMV/MVP is a complex entity with multiple genotypes and phenotypes in which the clinical manifestations may not be directly related to the severity of mitral regurgitation. Furthermore, there is a lack of a precise definition of this complex entity. This review emphasises a diagnostic approach based mostly on FMV rather than solely on MVP, which frequently may be a non-specific finding. In addition, a clinical classification of FMV/MVP is presented that separates patients with symptoms not directly related to the severity of mitral regurgitation (referred to as FMV/MVP syndrome) from those in whom symptoms are directly related to mitral regurgitation and its complications. In the future, genetic variants will likely be incorporated into the diagnostic classification and management of this complex entity as this odyssey continues.

Indexed as

classificationdiagnosisFloppy mitral valvemitral valve prolapsereview

Identifiers

PMID42741579
PMCPMC13573015

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.