Evidence map›Paper›PMID 42741553›Full record

ArticleFrontiers in immunology2026

Potential hazard assessment of 6PPD-quinone in the context of ulcerative colitis: network toxicology, machine learning, transcriptomic analysis, and preliminary

Jingyi Li, Xizhuang Gao, Yemin Xu, Lu Wang, Ying Zhu, Bin Deng

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In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jingyi LiDepartment of Gastroenterology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China.
Xizhuang GaoDepartment of Functional Examination, Zaozhuang Municipal Hospital, Jining Medical University, Zaozhuang, Shandong, China.
Yemin XuDepartment of Gastroenterology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China.
Lu WangDepartment of Gastroenterology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China.
Ying ZhuDepartment of Gastroenterology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China.
Bin DengDepartment of Gastroenterology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The ubiquitous tire-derived pollutant 6PPD-quinone (6PPD-Q) poses potential systemic health risks, yet its toxicological impact on the intestinal tract, particularly in the context of ulcerative colitis (UC), remains largely unknown. This study aimed to investigate whether 6PPD-Q aggravates DSS-induced colitis and to identify candidate molecular events using integrative computational and experimental approaches. Methods: An integrative strategy combining network toxicology, machine learning, public bulk- and single-cell transcriptomic analyses, molecular simulations, and preliminary Results: Through multidimensional screening, we identified five core regulatory genes ( Conclusions: This study provides an integrative mechanistic framework for investigating the potential intestinal effects of 6PPD-Q under inflammatory conditions. By integrating computational target prioritization with

Indexed as

Colitis, UlcerativeMachine LearningTranscriptomeAnimalsBenzoquinonesColonDextran SulfateDisease Models, AnimalGene Expression ProfilingMaleMiceMice, Inbred C57BLMolecular Docking SimulationMolecular Dynamics SimulationPhenylenediaminesBenzoquinonesDextran SulfateN-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinonePhenylenediamines6PPD-quinoneadverse outcome pathwaymachine learningmolecular dynamicsnetwork toxicologyulcerative colitis

Identifiers

PMID42741553
PMCPMC13572913

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.