ArticleJournal of pain research2026
Motor Cortex rTMS Alleviates Pain and Comorbid Depression After Spinal Cord Injury with a Correlate in M1 Intracortical Inhibition.
Article in Journal of pain research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
Purpose: Neuropathic pain (NP) after spinal cord injury (SCI) is a debilitating syndrome, yet current treatments demonstrate limited efficacy. This randomized, double-blind, sham-controlled study investigated the analgesic efficacy of high-frequency repetitive transcranial magnetic stimulation (rTMS) over the left primary motor cortex (M1) and its neurophysiological mechanisms. Patients and Methods: Twenty-nine SCI patients with NP were randomly assigned (3:1) to receive either active rTMS (10 Hz, a total of 1200 pulses at an intensity of 80% resting motor threshold) or sham rTMS over the left M1 corresponding to the hand area once daily for two weeks. Pain intensity (Numeric Rating Scale, NRS), depression (9-item Patient Health Questionnaire, PHQ-9), and anxiety (7-item Generalized Anxiety Disorder Questionnaire, GAD-7) were assessed at baseline and after treatment. Furthermore, M1 intracortical excitability parameters, including short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF), were measured using paired-pulse TMS (ppTMS). Results: After the two-week intervention, active rTMS significantly reduced NRS scores ( Conclusion: These findings indicate that high-frequency rTMS alleviates NP and comorbid depression after SCI and is accompanied by changes in M1 intracortical inhibition. However, the 3:1 allocation resulted in a small sham group and limited statistical power for between-group comparisons, and confirmation in larger trials is required.
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