ArticleFrontiers in immunology2026
Case Report: Single-cell transcriptomic profiling of a pediatric ALK-negative gastric inflammatory myofibroblastic tumor.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal neoplasm, approximately 50% of which harbor ALK rearrangements. ALK-negative gastric IMT (G-IMT) in pediatric patients is exceptionally rare and poorly characterized. We report a 6-year-old male with fever, melena, and severe anemia (Hb 30 g/L). Imaging revealed a gastric fundus mass, and subtotal gastrectomy confirmed IMT with dense plasma-cell infiltrate and negative ALK immunostaining. We performed single-cell RNA sequencing on tumor and paired adjacent non-tumor tissue (14,103 cells). CellChat analysis inferred prominent CXCL12-CXCR4 communication between neoplastic myofibroblasts and immune cells. Macrophage subclustering identified an S100A9-high inflammatory tumor-associated macrophage state, and pseudotime analysis placed this state along a continuous transcriptional ordering with resident-like macrophages. To our knowledge, this is the first single-cell transcriptomic characterization of pediatric ALK-negative G-IMT and provides hypothesis-generating insight into its inflammatory microenvironment.
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