ArticleFrontiers in aging neuroscience2026
Inflammation and neuropsychiatric symptoms in Parkinson's disease: a genetic association.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: There has been some evidence that neuroinflammation is involved in Parkinson's disease (PD) and in psychiatric disorders. Objective: To explore the effects of IL-1β rs16944 on PD patients' neuropsychiatric symptoms. Methods: Two hundred and eighty-one consecutive PD patients underwent a neurological and neuropsychological evaluations, which included: Unified Parkinson's Disease Rating Scale, Schwab and England Activities of Daily Living scale, Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Anytime Short, Hospital Anxiety and Depression Scale and Dementia Rating Scale-2. The Neuropsychiatric Inventory (NPI) was also applied to patients' caregivers/informants. In addition to IL-1β rs16944, DRD3 rs6280 and GRIN2B rs7301328 were also genotyped. Non-parametric group comparisons and linear and logistic regressions were used for data analyses. Results: The IL-1β rs16944 (specifically TT vs. CC) genotype was associated with increased frequency of impulse-control behaviors and disorders (ICBDs) and impulse control disorders (ICDs; OR = 3.54, Conclusion: Study findings suggest that a polymorphism previously associated with increased IL-1β expression may increase the risk of certain neuropsychiatric symptoms in PD.
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