Evidence map›Paper›PMID 42741323›Full record

ArticleACS medicinal chemistry letters2026

Nitrile-Based Inhibitors Targeting both SARS-CoV‑2 Main Protease and Human Cathepsin L.

Leonard Barasa, Yongzhi Chen, Ala M Shaqra, Syeda F Z Adnan, Lauren E Intravaia, Sandeep Huchaiah, Akumalla Allabaji, Karthik Kumar S, Srinivasa Rao Vidadala, Santoshkumar N Patil and 4 more

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Leonard BarasaProgram in Chemical Biology, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, United States.ORCID https://orcid.org/0009-0000-4519-0125
Yongzhi ChenDivision of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, United States.
Ala M ShaqraDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, United States.
Syeda F Z AdnanDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, United States.
Lauren E IntravaiaDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, United States.ORCID https://orcid.org/0000-0001-7126-2495
Sandeep HuchaiahSyngene International Ltd., Bommasandra-Jigani Link Road, Biocon Park, Bangalore 560100 India.
Akumalla AllabajiSyngene International Ltd., Bommasandra-Jigani Link Road, Biocon Park, Bangalore 560100 India.
Karthik Kumar SSyngene International Ltd., Bommasandra-Jigani Link Road, Biocon Park, Bangalore 560100 India.
Srinivasa Rao VidadalaSyngene International Ltd., Bommasandra-Jigani Link Road, Biocon Park, Bangalore 560100 India.
Santoshkumar N PatilSyngene International Ltd., Bommasandra-Jigani Link Road, Biocon Park, Bangalore 560100 India.
Jeffrey HaleHale MedChem Advisors LLC, 233 Hazel Avenue, Westfield, New Jersey 07090, United States.
Celia A SchifferDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, United States.ORCID https://orcid.org/0000-0003-2270-6613
Katherine A FitzgeraldDivision of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, United States.
Paul R ThompsonProgram in Chemical Biology, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, United States.ORCID https://orcid.org/0000-0002-1621-3372

Funding

Chemical probes to decipher PAD biologyR35GM118112 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Paul R Thompson · 2016 to 2026
$9.5M
NIGMS NIH HHS R35 GM118112
6 · The paper itself

Abstract

The SARS-CoV-2 main protease (M

Indexed as

Antiviral agentsDual inhibitorsHuman cathepsin LSARS-CoV-2 Mpro

Identifiers

PMID42741323
PMCPMC13573261

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.