ArticleFrontiers in psychology2026
Effects of stressful life events on ART treatment outcomes: a prospective study on the role of individual and personality characteristics and psychological health conditions.
Article in Frontiers in psychology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Infertility research highlighted that early exposure to stressful life events (SLEs) and childhood adversities are significantly associated not only with women's psychological health, but also with outcomes of assisted reproductive technologies. Nevertheless, there is a lack of studies adopting a multidimensional and transactional approach exploring how early life and family-related stressors potentially influence treatment outcomes through multiple interacting variables. Objective: The present study aimed to test the associations between stressful life events and ART treatment outcomes (Failure/Success) by also exploring the potential mediating role of psychological health conditions (State-Anxiety and Depression) and the moderating role of socio-demographics, infertility-related parameters, and personality characteristics. Methods: A prospective study was conducted. At the beginning of ART treatment (T1, 2020), 130 infertile women completed self-report measures assessing individual (socio-demographics) and personality (coping strategies) characteristics, fertility-related parameters, SLEs (In Family Pre-existing Pregnancy Difficulties; Problems in Family of Origin; Health Problems in Childhood), and psychological health conditions (State-Anxiety/Depression). After 5 years (T2, 2025), medical records were reviewed to verify treatment outcomes. Main/mediating/moderating hypotheses were tested by using Correlational-Analyses and Hayes-PROCESS-tool. Results: Conclusion: These findings underscore the influence of stressful life events on ART outcomes
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