Evidence map›Paper›PMID 42741292›Full record

ArticleACS medicinal chemistry letters2026

Discovery and Structure-Activity Relationship Studies of Thienopyrroles as Group 2 Influenza A Entry Inhibitors.

John P Sloan, Ryan Bott, Carolina Q Sacramento, Christian Zielinski, Destiny I Durante, Norton P Peet, Irina N Gaisina, Lijun Rong, Terry W Moore

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

John P SloanDepartment of Pharmaceutical Sciences, University of Illinois Chicago, Chicago, Illinois 60612, United States.ORCID https://orcid.org/0009-0005-0878-7607
Ryan BottDepartment of Microbiology and Immunology, University of Illinois Chicago, Chicago, Illinois 60612, United States.
Carolina Q SacramentoDepartment of Microbiology and Immunology, University of Illinois Chicago, Chicago, Illinois 60612, United States.
Christian ZielinskiUICentre for Drug Discovery, University of Illinois Chicago, Chicago, Illinois 60612, United States.ORCID https://orcid.org/0009-0009-0832-1814
Destiny I DuranteDepartment of Pharmaceutical Sciences, University of Illinois Chicago, Chicago, Illinois 60612, United States.ORCID https://orcid.org/0000-0003-3638-968X
Norton P PeetChicago BioSolutions Inc., Chicago, Illinois 60612, United States.
Irina N GaisinaDepartment of Pharmaceutical Sciences, University of Illinois Chicago, Chicago, Illinois 60612, United States.ORCID https://orcid.org/0000-0002-8668-3222
Lijun RongDepartment of Microbiology and Immunology, University of Illinois Chicago, Chicago, Illinois 60612, United States.
Terry W MooreDepartment of Pharmaceutical Sciences, University of Illinois Chicago, Chicago, Illinois 60612, United States.ORCID https://orcid.org/0000-0002-5410-306X

Funding

Development of 4-(aroylamino)piperidine-based entry inhibitors as anti-influenza therapeuticsR42AI155039 · NIAID · CHICAGO BIOSOLUTIONS, INC. · PI RONG, LIJUN · 2021 to 2024
$3.3M
Development of group 2 influenza A virus entry inhibitorsR41AI145727 · NIAID · CHICAGO BIOSOLUTIONS, INC. · PI RONG, LIJUN · 2019 to 2020
$600k
NIAID NIH HHS R41 AI145727NIAID NIH HHS R42 AI155039
6 · The paper itself

Abstract

The influenza A virus has been detrimental to public health for centuries and continues to take the lives of tens of thousands of people annually. Although current therapeutics have been effective in the past, the emergence of drug-resistant strains underscores the need for agents with new mechanisms of action. Here, we report thieno-[3,2-

Indexed as

heterocyclic compoundsinfluenza A inhibitorsthienopyrroles

Identifiers

PMID42741292
PMCPMC13573256

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.