ArticleFrontiers in pediatrics2026
Postprandial decline in abdominal regional oxygen saturation is associated with feeding intolerance in preterm infants: a prospective cohort study.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Feeding intolerance (FI) is a common morbidity in preterm infants, often preceding necrotizing enterocolitis (NEC). Near-infrared spectroscopy (NIRS) monitoring of abdominal regional oxygen saturation (A-rSO2) may detect impaired intestinal hemodynamics before clinical symptoms appear. Objective: To investigate the relationship between A-rSO2 patterns and feeding tolerance in preterm infants. Methods: A prospective observational cohort study of 30 preterm infants <37 weeks of gestation admitted at Dongguan Children's Hospital Affiliated to Guangdong Medical University between December 2020 to September 2021. A-rSO2 was measured pre-prandially (mean over a 10 min stable period) and post-prandially (mean commencing 30 min after feeding). Infants were stratified into FI ( Results: The incidence of FI was 23.3%, and NEC was 10%. Infants with FI had significantly lower gestational age (32.1 vs. 35.2 weeks, Conclusion: A postprandial decline in A-rSO2 may be a potential factor associated with feeding intolerance in preterm infants. NIRS monitoring of intestinal oxygenation provides a physiological indicator that warrants further investigation as a factor associated with gut dysfunction. These findings are hypothesis-generating and require validation in larger cohorts.
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