Evidence map›Paper›PMID 42741242›Full record

ArticleThe World Allergy Organization journal2026

Real-world effectiveness of fluticasone propionate-azelastine nasal spray in moderate-to-severe nonallergic and perennial allergic rhinitis.

Piyaporn Chokevittaya, Noraworn Jirattikanwong, Phanu Prasankiattirach, Chamard Wongsa, Norapat Limsirorat, Pasiri Jungsanguanpornsuk, Mongkhon Sompornrattanaphan, Kawita Atipas, Navarat Kasemsuk, Dichapong Kanjanawasee and 6 more

Abstract read
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In one paragraph

Article in The World Allergy Organization journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Piyaporn ChokevittayaDivision of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Noraworn JirattikanwongCenter for Clinical Epidemiology and Clinical Statistics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Phanu PrasankiattirachCenter for Clinical Epidemiology and Clinical Statistics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Chamard WongsaDivision of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Norapat LimsiroratDivision of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Pasiri JungsanguanpornsukDivision of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Mongkhon SompornrattanaphanDivision of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Kawita AtipasDivision of Rhinology and Allergy, Department of Otorhinolaryngology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Navarat KasemsukDivision of Rhinology and Allergy, Department of Otorhinolaryngology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Dichapong KanjanawaseeDepartment of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Triphoom SuwanwechDivision of Rhinology and Allergy, Department of Otorhinolaryngology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Pongsakorn TantilipikornDivision of Rhinology and Allergy, Department of Otorhinolaryngology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Wannada LaisuanDivision of Allergy, Immunology and Rheumatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Phichayut PhinyoCenter for Clinical Epidemiology and Clinical Statistics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Jonathan A BernsteinDivision of Rheumatology, Allergy and Immunology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, USA.
Torpong ThongngarmDivision of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Although combined intranasal corticosteroid-antihistamine sprays are approved for allergic rhinitis, evidence supporting their effectiveness in nonallergic rhinitis (NAR) remains limited. Objective: To compare the treatment response to fluticasone propionate-azelastine (FP-Aze) for treating NAR and perennial allergic rhinitis (PAR). Methods: This prospective observational real-world study enrolled adults with moderate-to-severe PAR or NAR. Participants received FP-Aze nasal spray (50/137 μg), 1 spray per nostril twice daily for 4 weeks. The primary endpoint was the change from baseline in the visual analog scale (VAS) for rhinitis, ranging from 0 to 100 mm. Treatment effectiveness in NAR was assessed for noninferiority, with a prespecified margin of 23 mm on the VAS relative to PAR. Secondary outcomes included evaluation of non-nasal symptoms and quality of life (QoL). Results: Patients with moderate-to-severe PAR ( Conclusion: The effectiveness of FP-Aze in moderate-to-severe NAR was noninferior to PAR on the VAS for rhinitis, supporting its use in this population. These findings help address an important evidence gap, as data supporting FP-Aze in NAR remain limited.

Indexed as

Allergic rhinitisFluticasone propionate-azelastineNonallergic rhinitisQuality of lifeVisual analog scale

Identifiers

PMID42741242
PMCPMC13572997

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.