ArticleCureus2026
Physiological Factors of Exercise Intolerance in Patients With Pectus Excavatum: A Retrospective, Single-Center Study.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
introductionPectus excavatum (PE) causes a sunken thoracic wall, which is associated with adolescent exercise intolerance. Since the underlying physiological factors remain uncertain, this retrospective chart review addressed this knowledge gap by reviewing cardiopulmonary exercise tests (CPETs) and identifying physiological factors of exercise intolerance.
methodsWith the Nemours Institutional Review Board's approval (IRB approval number: STUDY00000806), this study enrolled patients with PE who underwent CPET and chest magnetic resonance imaging (MRI) for Haller index at the Nemours Children's Hospital, Orlando, Florida, from January 2025 to January 2026. Inclusion criteria included age between 12 and 18 years, Haller index greater than 3.25, and completed CPET. Statistical analysis involved paired-sample parametric tests with Benjamini-Hochberg False Discovery Rate (FDR) adjustment and Spearman's rank correlation.
resultsTwenty-seven patients (23 male, age 14.9 ± 1.8 years) were enrolled. The mean Haller index was 5.8 ± 3.6. Patients with PE demonstrated significantly lower peak oxygen uptake (VO
conclusionExercise limitation in patients with PE was corroborated by low peak VO
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