Evidence map›Paper›PMID 42741156›Full record

ArticleResearch (Washington, D.C.)2026

Lymphatic-Immune Microenvironment Engineering via Rapamycin-Eluting Nanofibers for Meningeal Repair and Neuroprotection in Traumatic Brain Injury Rats.

Liyuan Zhong, Yu You Huang, Jiaxuan Xie, Xiaofei Han, Yumin Luo, Hanqi Liu, Chunhao Yu, Yi Ming Huang, Yufeng Zheng, Hao Sun and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Liyuan ZhongDepartment of Neurology and Institute of Cerebrovascular Diseases Research, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.ORCID https://orcid.org/0009-0006-5511-6432
Yu You HuangDepartment of Neurology and Institute of Cerebrovascular Diseases Research, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
Jiaxuan XieAMT Medical Inc., Beijing 102629, China.
Xiaofei HanBeijing Institute of Brain Disorders, Capital Medical University, Beijing 100069, China.
Yumin LuoDepartment of Neurology and Institute of Cerebrovascular Diseases Research, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
Hanqi LiuBeijing Institute of Brain Disorders, Capital Medical University, Beijing 100069, China.
Chunhao YuSchool of Materials Science and Engineering, Peking University, Beijing 100083, China.
Yi Ming HuangDepartment of Neurology and Institute of Cerebrovascular Diseases Research, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
Yufeng ZhengSchool of Materials Science and Engineering, Peking University, Beijing 100083, China.
Hao SunAMT Medical Inc., Beijing 102629, China.
Qing LiuAMT Medical Inc., Beijing 102629, China.
Zhi LiuEmergency Department, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
Di WuNeuro-Cardiovascular Research Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
Xunming JiDepartment of Neurology and Institute of Cerebrovascular Diseases Research, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
Miaowen JiangBeijing Institute of Brain Disorders, Capital Medical University, Beijing 100069, China.
Ming LiDepartment of Neurology and Institute of Cerebrovascular Diseases Research, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While current dural repair patches achieve mechanical sealing to prevent cerebrospinal fluid leakage, they fail to address the critical pathological cascades of traumatic brain injury, including structural disruption of meningeal lymphatic vessels and dysregulation of neuroimmune responses. Here, we break this therapeutic stalemate through lymphatic-immune microenvironment engineering using rapamycin-eluting poly(l-lactide-

Identifiers

PMID42741156
PMCPMC13572802

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.