ArticleFrontiers in psychology2026
Effects of a 12-week high-intensity interval training intervention on serum neurotransmitters and autonomic function in mild-to-moderate depression.
Article in Frontiers in psychology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Exercise is increasingly recognized as an effective adjunctive treatment for depression; however, the neurobiological mechanisms underlying its antidepressant effects remain incompletely understood. This study investigated whether a 12-week high-intensity interval training (HIIT) program could alleviate depressive symptoms by modulating peripheral neurotransmitter profiles and autonomic nervous system function in university students with mild-to-moderate depression. Methods: A total of 34 university students (18-25 years) with mild-to-moderate depression were enrolled and allocated to either an exercise group (EXD, Results: Compared with the CON group, participants in the EXD group exhibited significantly greater reductions in BDI and HAMD-17 scores, accompanied by marked increases in serum 5-HT and BDNF levels and significant decreases in cortisol and glutamate concentrations ( Conclusion: A 12-week HIIT program effectively alleviated depressive symptoms and improved autonomic nervous system function in young adults with mild-to-moderate depression.
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