ArticleFrontiers in medicine2026
Reproductive lifespan and cardiovascular health in postmenopausal women: a non-linear, behavior-driven association with cross-population validation.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Reproductive lifespan (RLS), the interval from menarche to natural menopause, has been associated with cardiovascular disease (CVD) risk. However, most prior studies have assumed a linear relationship, and the potential non-linearity of this association, as well as the underlying behavioral and biological mechanisms, remain largely unexplored. Methods: This cross-sectional study included 1,673 naturally postmenopausal women (weighted Results: RLS exhibited a significant inverted U-shaped association with LS7 (P for non-linearity = 0.025). In the ascending segment (RLS ≤ 37 years), each additional year of RLS was associated with a higher LS7 score (β = 0.038, Conclusion: In naturally postmenopausal women, RLS showed an inverted U-shaped association with cardiovascular health, peaking at approximately 37 years. This association was partially mediated by NLR and driven entirely by behavioral components. These findings support incorporating reproductive history into cardiometabolic risk assessment and highlight behavioral interventions for women with shorter reproductive lifespans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.