ArticleFrontiers in veterinary science2026
The potential protective roles of Astragalus polysaccharides against toxicity of polystyrene nanoplastics on mice sperm exposed.
Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Polystyrene nanoparticles (PS-NPs) damage the male reproductive system, although the potential impacts on mammalian reproductive health remain unclear. The aim of this study was to determine the protective effect of Methods: Male mice were randomly assigned to three groups (n = 6 each): control, PS-NPs at 50 mg/kg/day (P group), and PS-NPs at 50 mg/kg/day plus APS at 100 mg/kg/day (P+A group), aimed to elucidate the molecular mechanisms of PS-NPs exposure on sperm and the protective effects of APS. Testicular microstructure and function, serum testosterone level, enrichment of PS-NPs in the epididymis, sperm morphology and motility, concentration of zinc ions, the CuZn-superoxide dismutase activity (SOD) activity, total antioxidant capacity (T-AOC), malondialdehyde content (MDA) in seminal plasma, and protein tyrosine phosphorylation of non-/capacitated sperm were evaluated. Results: Exposure to PS-NPs significantly decreased the percentage of normal seminiferous tubules and serum testosterone levels ( Discussion: APS relieved oxidative damage to sperm, enhanced antioxidant capacity, and protected against testicular and epididymal damage caused by exposure to PS-NPs. APS regulated protein tyrosine phosphorylation to prevented the of "capacitation-like" phenomenon of non-capacitated sperm caused by PS-NPs. Meanwhile, APS alleviated the decrease in proteins tyrosine phosphorylation of capacitated sperm exposed by PS-NPs. These results indicate that APS could be used to ameliorate sperm quality induced by environmental toxins.
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