Evidence map›Paper›PMID 42741138›Full record

ArticleUrology case reports2026

Metastatic adenocarcinoma centered in the male urethra with intestinal differentiation and uncertain accessory-gland origin presenting as urethral stricture: a case report.

Francesco Trama, Leo Romis, Giovanni Maria Fusco, Mirko Punziano, Daniele Masala, Maria Rosaria Nugnes, Filippo Riccardo, Stefano Lai, Salvatore Mordente, Modestino Giovanni Tronino and 2 more

Abstract readCase Reports
In one paragraph

Article in Urology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Francesco TramaDepartment of Urology, ASL Napoli 2 Nord, P.O. Santa Maria delle Grazie, Pozzuoli, Naples, Italy.
Leo RomisDepartment of Urology, ASL Napoli 2 Nord, P.O. Santa Maria delle Grazie, Pozzuoli, Naples, Italy.
Giovanni Maria FuscoDepartment of Urology, ASL Napoli 2 Nord, P.O. Santa Maria delle Grazie, Pozzuoli, Naples, Italy.
Mirko PunzianoDepartment of Urology, ASL Napoli 2 Nord, P.O. Santa Maria delle Grazie, Pozzuoli, Naples, Italy.
Daniele MasalaDepartment of Urology, ASL Napoli 2 Nord, P.O. Santa Maria delle Grazie, Pozzuoli, Naples, Italy.
Maria Rosaria NugnesDepartment of Urology, ASL Napoli 2 Nord, P.O. Santa Maria delle Grazie, Pozzuoli, Naples, Italy.
Filippo RiccardoDepartment of Urology, ASL Napoli 2 Nord, P.O. Santa Maria delle Grazie, Pozzuoli, Naples, Italy.
Stefano LaiDepartment of Urology, ASL Napoli 2 Nord, P.O. Santa Maria delle Grazie, Pozzuoli, Naples, Italy.
Salvatore MordenteDepartment of Urology, ASL Napoli 2 Nord, P.O. Santa Maria delle Grazie, Pozzuoli, Naples, Italy.
Modestino Giovanni TroninoDepartment of Urology, ASL Napoli 2 Nord, P.O. Santa Maria delle Grazie, Pozzuoli, Naples, Italy.
Ester IllianoAndrology and Urogynecology Clinic, Santa Maria Terni Hospital, University of Perugia, Piazzale Tristano di Joanuccio 1, Terni, 05100, Italy.
Giovanni Di LauroDepartment of Urology, ASL Napoli 2 Nord, P.O. Santa Maria delle Grazie, Pozzuoli, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 45-year-old man with recurrent urinary retention and inflammatory-appearing urethral strictures was diagnosed after biopsy with tubulo-papillary adenocarcinoma showing intestinal differentiation. MRI revealed a bulky bulbar-penile urethral mass invading both corpora cavernosa, with nodal and bone disease. The accessory-gland origin remained uncertain, and a gastrointestinal primary could not be conclusively excluded. Six cycles of cisplatin-gemcitabine produced regression of abdominal-pelvic lymphadenopathies but progression of the urethral lesion, indicating a mixed response. Palliative radiotherapy and surgery for a severe penoscrotal infectious complication were required. The patient subsequently deteriorated and died in 2025.

Indexed as

Cowper glandIntestinal differentiationLittré glandMixed responseUrethral adenocarcinomaUrethral stricture

Identifiers

PMID42741138
PMCPMC13572737

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.