ArticleFrontiers in endocrinology2026
Association between the triglyceride-glucose index and the presence and severity of hemorrhoidal disease: a cross-sectional study based on retrospectively collected clinical data.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate the association between the triglyceride-glucose (TyG) index and the prevalence and severity of hemorrhoidal disease in adults undergoing anorectal evaluation. Methods: This cross-sectional study analyzed retrospectively collected data from 528 adults undergoing anorectal evaluation and fasting biochemical testing. The TyG index was calculated as ln[fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2]. Multivariable logistic regression, restricted cubic spline analysis, subgroup, sensitivity, severity, and exploratory mediation analyses were performed to assess the association between TyG and hemorrhoidal disease. Results: Among the 528 participants, 196 (37.1%) had hemorrhoidal disease. Its prevalence increased progressively across TyG quartiles, from 23.5% in Q1 to 53.8% in Q4 (P for trend<0.001). After adjustment for demographic, metabolic, lifestyle, medication-related, and bowel-related factors, each 1-unit increase in the TyG index was associated with higher odds of hemorrhoidal disease (OR = 1.68, 95% CI: 1.24-2.28; P = 0.001). Compared with Q1, participants in Q4 had significantly greater odds of hemorrhoidal disease (OR = 2.43, 95% CI: 1.34-4.41; P for trend=0.002). Restricted cubic spline analysis showed a significant overall association (P<0.001) without evidence of nonlinearity (P = 0.184). The findings remained consistent across subgroup and sensitivity analyses. A higher TyG index was also associated with advanced hemorrhoidal disease (OR per 1-unit increase=1.62, 95% CI: 1.01-2.61). Conclusion: A higher TyG index was independently associated with hemorrhoidal disease severity. BMI partially mediated this association (~27%), suggesting a potential metabolic pathway that requires validation in longitudinal studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.