SynthesisFrontiers in aging neuroscience2026
The gut microbiota dysbiosis in ischemic stroke: a systematic review and meta-analysis of microbial diversity and taxonomic alterations.
Synthesis in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Clinical and epidemiological evidence suggests a link between gut microbiota and ischemic stroke severity as well as outcomes, yet inconsistent findings and unclear mechanisms underscore the need for a systematic synthesis. Methods: We systematically reviewed and meta-analyzed observational studies linking gut microbiota to ischemic stroke, following PRISMA guidelines. The search covered PubMed, Embase, and the Cochrane Library, with animal studies and Results: From 17,281 initially identified records, 59 studies involving 7,463 patients were included in the final analysis. Although α-diversity measures-including Shannon, Chao1, ACE, Simpson index, and observed species richness-did not differ significantly between ischemic stroke patients and controls (all Conclusion: Ischemic stroke is characterized by taxonomic gut dysbiosis, whereas a decrease in α-diversity is observed only in patients who also develop cognitive impairment and mood disorders after stroke. Future multi-omics and large cohort studies should establish causality between gut microbiota and ischemic stroke, identifying therapeutic targets. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024506656, Identifier: CRD42024506656.
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