ArticleFrontiers in behavioral neuroscience2026
Home-based cognitive telerehabilitation in multiple sclerosis: differential cognitive trajectories according to baseline impairment severity.
Article in Frontiers in behavioral neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Although cognitive impairment (CI) is common in multiple sclerosis (MS), conventional cognitive rehabilitation is often limited by accessibility and adherence challenges. Telerehabilitation offers an accessible alternative, but its efficacy across different CI severity levels remains unclear. The present prospective, single-center, single-arm interventional study with repeated measures aimed to identify changes in cognitive and psychosocial outcomes following a home-based cognitive telerehabilitation program with weekly synchronous coaching in MS patients with mild versus moderate CI, and to explore whether baseline impairment severity was associated with differences in change over time. Methods: Sixty-six MS patients (34 mild CI; 32 moderate CI) completed a 12-week home-based cognitive telerehabilitation program (five sessions/week), supported by weekly Skype coaching. Outcomes were assessed at baseline (T0), post-intervention (T1), and 3-month follow-up (T2). Cognitive and emotional-behavioral functioning were investigated using standardized, validated instruments in the MS population. Changes over time and between-group differences were analyzed using linear models. Results: At T1, both groups improved in attention, verbal memory, and subjective cognitive perception (all Conclusion: Following the intervention, both groups showed improvements in cognitive and emotional-behavioral outcomes, with larger and more sustained changes in mild CI. These findings should be confirmed in randomized controlled studies.
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