Evidence map›Paper›PMID 42741038›Full record

ArticleFrontiers in veterinary science2026

Short-term supplementation of thymol and carvacrol regulates feed intake via the hypothalamic PI3K/AKT/SF-1 pathway and influences intestinal traits in chicks.

Ling Zhou, Zhiyong Huang, Jiancong Zhang, Xin Li, Shiping Bai, Fan Lei, Yutong Zou, Yue Zhang, Pinyao Zhao, Liguo Yin and 1 more

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Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ling Zhou *Solid-State Fermentation Resource Utilization Key Laboratory of Sichuan Province, Faculty of Quality Management and Inspection Quarantine, Sichuan Higher Education Engineering Research Center for Agri-Food Standardization and Inspection, Yibin University, Yibin, China.
Zhiyong Huang *Key Laboratory of Animal Disease-Resistance Nutrition, Ministry of Agriculture and Rural Affairs, Key Laboratory of Sichuan Province, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
Jiancong Zhang *Key Laboratory of Animal Disease-Resistance Nutrition, Ministry of Agriculture and Rural Affairs, Key Laboratory of Sichuan Province, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
Xin LiInstitute of Brain Science and Diseases, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Shiping BaiKey Laboratory of Animal Disease-Resistance Nutrition, Ministry of Agriculture and Rural Affairs, Key Laboratory of Sichuan Province, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
Fan LeiInstitute of Brain Science and Diseases, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yutong ZouSolid-State Fermentation Resource Utilization Key Laboratory of Sichuan Province, Faculty of Quality Management and Inspection Quarantine, Sichuan Higher Education Engineering Research Center for Agri-Food Standardization and Inspection, Yibin University, Yibin, China.
Yue ZhangSolid-State Fermentation Resource Utilization Key Laboratory of Sichuan Province, Faculty of Quality Management and Inspection Quarantine, Sichuan Higher Education Engineering Research Center for Agri-Food Standardization and Inspection, Yibin University, Yibin, China.
Pinyao ZhaoSolid-State Fermentation Resource Utilization Key Laboratory of Sichuan Province, Faculty of Quality Management and Inspection Quarantine, Sichuan Higher Education Engineering Research Center for Agri-Food Standardization and Inspection, Yibin University, Yibin, China.
Liguo YinSolid-State Fermentation Resource Utilization Key Laboratory of Sichuan Province, Faculty of Quality Management and Inspection Quarantine, Sichuan Higher Education Engineering Research Center for Agri-Food Standardization and Inspection, Yibin University, Yibin, China.
Li LvKey Laboratory of Animal Disease-Resistance Nutrition, Ministry of Agriculture and Rural Affairs, Key Laboratory of Sichuan Province, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: This study investigated the effects of dietary supplementation with thymol, carvacrol, and NE150 (a commercial blend containing 25% thymol and 25% carvacrol) at 120 mg/kg on growth performance and feed intake, hypothalamic appetite-regulating gene expression and PI3K/AKT/SF-1 signaling, as well as intestinal morphology and cecal microbiota in broiler chicks. Methods: Based on preliminary dose-finding experiments (60, 120, and 240 mg/kg), the 120 mg/kg dose was selected for each additive as it showed the most favorable effects on growth performance (data not shown). A total of 180 one-day-old Arbor Acres male chicks were fed a basal diet from day 1 to 10, followed by a 3-day treatment period (days 10-13) with the respective diets. Results: Compared with the control group, total feed intake at 72 h was reduced by thymol, carvacrol, and NE150 ( Discussion: These findings indicate that thymol and carvacrol suppress feed intake in broiler chicks, at least in part, through activation of the hypothalamic PI3K/AKT/SF-1 pathway, while also improving intestinal morphology and cecal microbiota composition. These results suggest that thymol and carvacrol may serve as effective antibiotic alternatives in poultry nutrition.

Indexed as

feed intakeintestinal traitsPI3K/AKT/SF-1 pathwayshort-term feedingthymol and carvacrol

Identifiers

PMID42741038
PMCPMC13572108

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.