ArticleJID innovations : skin science from molecules to population health2026
Autophagy-dependent changes in the sebaceous gland and epidermal lipid distribution localized by mass spectrometric imaging.
Article in JID innovations : skin science from molecules to population health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Sebum is a lipid mixture produced and delivered to the skin surface by appendages called sebaceous glands (SGs) in a holocrine secretion process. Sebum contributes to the skin barrier, lubricates hair and skin, provides antimicrobial protection, and has pheromone functions. During the terminal differentiation of SG cells (sebocytes), macroautophagy, an intracellular process for major metabolic reconfiguration, is activated. Deletion of autophagy affects the hair sebum composition in mice. This study aimed to investigate lipid composition and localization within SG and the epidermis in
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