Evidence map›Paper›PMID 42740888›Full record

ArticleClinical and translational radiation oncology2026

Outcomes of elderly patients treated with chemoradiotherapy for anal squamous cell carcinoma: a multicenter study of the German cancer consortium - radiation oncology group (DKTK-ROG).

D Martin, F Rödel, G Kalinauskaite, I Tinhofer, D Zips, C Gani, T Schimek-Jasch, H Schäfer, A L Grosu, E Thomas and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and translational radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

D MartinDepartment of Radiotherapy and Oncology, University Hospital, Goethe University, Frankfurt, Germany.
F RödelDepartment of Radiotherapy and Oncology, University Hospital, Goethe University, Frankfurt, Germany.
G KalinauskaiteDepartment of Radiation Oncology, Charité-University Hospital Berlin, Berlin, Germany.
I TinhoferDepartment of Radiation Oncology, Charité-University Hospital Berlin, Berlin, Germany.
D ZipsDepartment of Radiation Oncology, Charité-University Hospital Berlin, Berlin, Germany.
C GaniDepartment of Radiation Oncology, Faculty of Medicine, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany.
T Schimek-JaschDepartment of Radiation Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Germany.
H SchäferDepartment of Radiation Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Germany.
A L GrosuDepartment of Radiation Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Germany.
E ThomasOncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TU, Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Germany.
M KrauseOncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TU, Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Germany.
H DapperDepartment of Radiation Oncology, Technical University Munich (TUM), Munich, Germany.
S CombsDepartment of Radiation Oncology, Technical University Munich (TUM), Munich, Germany.
C HoffmannDepartment of Radiotherapy, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
M StuschkeDepartment of Radiotherapy, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
F WalterGerman Cancer Consortium (DKTK), Partner Site Munich, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
C BelkaGerman Cancer Consortium (DKTK), Partner Site Munich, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
I KurthGerman Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) Core Center, Heidelberg, Germany.
W W HadiwikartaGerman Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) Core Center, Heidelberg, Germany.
M BaumannGerman Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) Core Center, Heidelberg, Germany.
C RödelDepartment of Radiotherapy and Oncology, University Hospital, Goethe University, Frankfurt, Germany.
E FokasDepartment of Radiotherapy and Oncology, University Hospital, Goethe University, Frankfurt, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Older patients with anal squamous cell carcinoma (ASCC) are underrepresented in prospective studies evaluating chemoradiotherapy (CRT). We evaluated patient-/tumor-/treatment characteristics and oncologic outcomes in older patients treated with CRT in a large retrospective multicenter cohort study of the DKTK-ROG. Materials and Methods: Patients with localized ASCC treated with CRT between 2004 and 2018, were retrospectively analyzed. Older patients were defined as age ≥ 70 years at CRT initiation. Freedom from recurrence (FFR) and overall survival (OS) were analyzed using Kaplan-Meier estimates, competing-risk analyses, and Cox regression models. Results: A total of 683 patients were analyzed, including 180 older patients (≥70 years, 26%). The 3-year FFR and OS rates for the entire cohort were 80.0% (95% CI, 76.9-83.3%) and 87.1% (95% CI 84.5-89.9%), respectively. Competing risk regression for locoregional failure including non complete response or distant metastases with death as competing risk revealed no significant difference between both groups ( Interpretation: Definitive CRT provides meaningful oncologic control in selected older patients with localized ASCC. Chronological age alone should not preclude curative-intent treatment. Future studies should integrate geriatric assessment to better individualize treatment strategies in older patients.

Indexed as

Anal cancerChemoradiotherapyElderlyMulticenter cohortOutcome

Identifiers

PMID42740888
PMCPMC13571947

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.