Evidence map›Paper›PMID 42740801›Full record

ArticleiScience2026

Valproic acid remodels phosphatidylglycerol homeostasis and epithelial-macrophage crosstalk in inflammatory signaling.

Ivana Ďurišová, Mariana Máčajová, Ingrid Zriniová, Ivana Fábryová, Mailinda Meta, Lenka Bábelová, Boris Bilčík, Aleš Kvasnička, Miroslav Baláž, Soňa Bernátová and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ivana ĎurišováDepartment of Membrane Biochemistry, Centre of Biosciences, Slovak Academy of Sciences, Institute of Animal Biochemistry and Genetics, Bratislava, Slovakia.
Mariana MáčajováDepartment of Physiology and Ethology, Centre of Biosciences, Slovak Academy of Sciences, Institute of Animal Biochemistry and Genetics, Bratislava, Slovakia.
Ingrid ZriniováDepartment of Membrane Biochemistry, Centre of Biosciences, Slovak Academy of Sciences, Institute of Animal Biochemistry and Genetics, Bratislava, Slovakia.
Ivana FábryováDepartment of Membrane Biochemistry, Centre of Biosciences, Slovak Academy of Sciences, Institute of Animal Biochemistry and Genetics, Bratislava, Slovakia.
Mailinda MetaDepartment of Physiology and Ethology, Centre of Biosciences, Slovak Academy of Sciences, Institute of Animal Biochemistry and Genetics, Bratislava, Slovakia.
Lenka BábelováDepartment of Membrane Biochemistry, Centre of Biosciences, Slovak Academy of Sciences, Institute of Animal Biochemistry and Genetics, Bratislava, Slovakia.
Boris BilčíkDepartment of Physiology and Ethology, Centre of Biosciences, Slovak Academy of Sciences, Institute of Animal Biochemistry and Genetics, Bratislava, Slovakia.
Aleš KvasničkaDepartment of Clinical Biochemistry, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czechia.
Miroslav BalážInstitute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia.
Soňa BernátováInstitute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
Silvia PetrezsélyováLaboratory of Immunobiology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Dominik FilippLaboratory of Immunobiology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Yuan-Hao HsuDepartment of Chemistry, Tunghai University, Taichung, Taiwan.
David FriedeckýInstitute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia.
Ivan ČavargaDepartment of Physiology and Ethology, Centre of Biosciences, Slovak Academy of Sciences, Institute of Animal Biochemistry and Genetics, Bratislava, Slovakia.
Mária BalážováDepartment of Membrane Biochemistry, Centre of Biosciences, Slovak Academy of Sciences, Institute of Animal Biochemistry and Genetics, Bratislava, Slovakia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary surfactant lipids support lung homeostasis and innate immunity, and their dysregulation contributes to acute respiratory distress syndrome. Whether mitochondrial phosphatidylglycerol (PG) biosynthesis influences epithelial lipid secretion and inflammatory responses remains unclear. Using A549 cells, we disrupted

Indexed as

inflammatory signalinglipid metabolismphosphatidylglycerolvalproic acid

Identifiers

PMID42740801
PMCPMC13571955

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.