ArticleRespiratory research & clinical practice2026
Phenotyping moderate asthma earlier by analyzing induced sputum eosinophils, blood eosinophils, and atopy: a cross-sectional comparison with severe asthma.
Article in Respiratory research & clinical practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: There has been limited research comparing the inflammatory characteristics of moderate and severe asthma in Brazil. To describe and compare the phenotypes of moderate asthma (MA) and severe asthma (SA) in Brazilian patients. Methods: In this cross-sectional study, we defined SA per the 2014 European Respiratory Society/American Thoracic Society criteria and MA per the 2018 GINA criteria. No participants had other lung diseases, recent respiratory infection, or a recent exacerbation. Asthma was characterized and phenotyped by using validated tests. Results: Compared to MA (n = 55), SA (n = 51) had more hospital (p < 0.001) and ICU admissions (p = 0.01), worse fixed airflow limitation (FEV Conclusions: Our analysis indicates that most subjects with SA or MA have the T2-high asthma phenotype, primarily allergic eosinophilic, in MA. Significant residual eosinophilic airway inflammation and recurrent exacerbations in some patients with MA suggest the need for further research on the optimal timing for.
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