ArticleJournal of Korean medical science2026
Evaluation of the Correlation of Calprotectin and SES-CD Score at the Time of Diagnosis and Follow-up After Diagnosis in Pediatric Patients With Crohn's Disease in Korea.
Article in Journal of Korean medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCrohn's disease (CD) requires reliable tools for monitoring intestinal inflammation. Fecal calprotectin (FC) has emerged as a promising non-invasive biomarker. This study aimed to evaluate the correlation between FC and endoscopic activity in pediatric CD confined to the colon and to establish FC cutoff values corresponding to disease severity and remission.
methodsWe conducted a multicenter, retrospective, cross-sectional study including 154 pediatric patients (< 19 years) with Paris classification L2, B1 CD from 15 centers in Korea (2017-2022). Simple Endoscopic Score for Crohn's Disease (SES-CD) and FC were assessed simultaneously at diagnosis and follow-up.
resultsAt diagnosis, the median FC was 1,355.0 mg/kg and SES-CD 14.0, with 39.6% classified as severe. At follow-up, the median FC was 126.0 mg/kg and SES-CD 2.0, with 50.7% achieving remission. FC correlated most strongly with SES-CD (
conclusionFC strongly correlates with endoscopic activity in pediatric colonic CD, surpassing clinical indices and serum markers. The identification of clinically meaningful cutoff values may reduce the need for repeated endoscopy and support the use of FC as a surrogate marker in real-world pediatric practice.
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