Evidence map›Paper›PMID 42740572›Full record

ArticleBrain and behavior2026

Altered Neurovascular Coupling Dynamics During Dobutamine-Induced Acute Stress.

Rui Wang, Pengling Ren, Xia Ma, Linkun Cai, Tingting Zhang, Fengxia Yu, Liang Zhu, Zhenghan Yang, Yawen Liu, Zhenchang Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rui WangPrecision and Intelligence Medical Imaging Lab, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Pengling RenPrecision and Intelligence Medical Imaging Lab, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Xia MaDepartment of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Linkun CaiPrecision and Intelligence Medical Imaging Lab, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Tingting ZhangDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Fengxia YuPrecision and Intelligence Medical Imaging Lab, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Liang ZhuRehabilitation Hospital Affiliated to National Research Center for Rehabilitation Technical Aids, Beijing, China.
Zhenghan YangDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Yawen LiuPrecision and Intelligence Medical Imaging Lab, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Zhenchang WangPrecision and Intelligence Medical Imaging Lab, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Peng-Gang QiaoDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Funding

Beijing Hospitals Authority Innovation Studio of Young Staff Funding Support 202302Beijing Scholar 2015Space Medical Experiment Project of the China Manned Space Program HYZHXM01012Space Medical Experiment Project of the China Manned Space Program HYZHXMH01005
6 · The paper itself

Abstract

backgroundNeurovascular coupling (NVC) is essential for regulating brain metabolism and energy supply and may be altered under acute stress. This study aimed to investigate how acute stress induced by dobutamine affects NVC. MATERIALS AND

methodsThis study enrolled 38 healthy participants undergoing a resting-state fMRI scan and an arterial spin labeling MRI scan prior to and during a stress test induced by dobutamine. Amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo), and cerebral blood flow (CBF) were calculated. Acrossvoxel CBF-ReHo and CBF-ALFF correlations were analyzed to evaluate the NVC within the whole gray matter, and the regional NVC of the brain was assessed with the CBF/ReHo and CBF/ALFF ratios.

resultsThe blood pressures at the ventricle systolic state (SBP) and diastolic state (DBP) were significantly increased after the infusion of dobutamine. The CBF/ReHo ratios in the postcentral cortex and the middle cingulate cortex under stress were significantly higher and lower, respectively, than the CBF/ReHo ratios in the postcentral cortex and the middle cingulate cortex under the resting state. Logistic regression analysis showed that DBP in the resting state (odds ratio [OR] 0.817, 95% confidence interval [CI] 0.692-0.965, p = 0.017) and SBP in the stress state (OR 1.218, 95% CI 1.067-1.390, p = 0.004) were significantly related to the increase in CBF/ReHo ratios in the left postcentral cortex.

conclusionDobutamine-induced acute stress modulated NVC dynamics. Participants with lower DBP in the resting state and higher SBP during acute stress were more prone to have increased NVC induced by stress. RELEVANCE STATEMENT: Acute cardiovascular stress induced by dobutamine altered neurovascular coupling dynamics, and individuals with lower resting diastolic pressure and greater systolic responses showed stronger stress-related NVC enhancement.

Indexed as

BrainCerebrovascular CirculationDobutamineNeurovascular CouplingStress, PhysiologicalAdultBlood PressureFemaleHumansMagnetic Resonance ImagingMaleYoung AdultDobutamineacute stresscerebral blood flowdobutamineneurovascular couplingresting‐state fMRI

Identifiers

PMID42740572
PMCPMC13575637

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.