SynthesisJournal of periodontology2026
Use of cells and/or biologics combined with scaffolds in alveolar bone augmentation for implant site development.
Synthesis in Journal of periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- New technologies in oral reconstructive medicine: Consensus report of the AAP/OF/SEPA Workshop.Journal of periodontology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundThe impact of adjunctive biologics and the use of cell-therapy has been sparsely explored. The objective of this systematic review is to evaluate the effectiveness/efficacy of these therapeutic modalities combined with scaffolds in alveolar bone augmentation for implant site development.
methodsAn electronic and manual was conducted. Clinical trials evaluating the effectiveness/efficacy and safety of biologics and cell-therapy combined with scaffolds used for bone alveolar augmentation procedures aiming at implant site development were eligible. The primary outcome was to assess the dimensional bone changes/gain, while the and secondary outcomes included histologic outcomes, patient-reported outcomes, complications and adverse effects. Meta-analysis was conducted only based on randomized clinical trials (RCTs). Moreover, risk of bias assessment of the selected investigations was also reported.
resultsOverall, after screening, 68 articles were eligible for qualitative synthesis. Of these, 56 were selected of which 23 RCTs (n
conclusionFindings from this review may suggest that biologics combined with scaffolds in alveolar ridge augmentation procedures may elicit superior outcomes in terms of dimensional bone gain and histological new bone formation compared to the use of grafts without applying biologics. Biologics and cell-therapy are suggested to be safe and effective in alveolar bone augmentation interventions pursuing implant site development. PLAIN LANGUAGE SUMMARY: In recent years, researchers have been studying special biological products, called biologics, to help improve bone growth before placing dental implants. These products include things like growth factors or cells that can speed up healing and help new bone form. Our review demonstrates that when biologics are used together with bone graft materials, they appear to be safe and may lead to better bone growth and shape compared to traditional treatments. Patients also seem to prefer biologics especially when they come from their own blood because they may reduce pain and swelling after surgery. For procedures that lift the sinus to create more space for implants, using biologics did not show clear differences in bone height or appearance on X-rays, although the bone healing process may change slightly when these products are used. Cell-based therapies also seem safe and may work well, but there are not yet enough studies to prove they are better than traditional bone grafting methods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.