Evidence map›Paper›PMID 42740428›Full record

ReviewImmunological reviews2026

Human Peripheral B Cell Subsets: Evolving notions about B cell biology and the broad relevance of B cells in disease.

Shiv Pillai, Elif Çakan, Anson Hui

Abstract readReview
In one paragraph

Review in Immunological reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shiv PillaiRagon Institute of Mass General Brigham, MIT and Harvard, Cambridge, Massachusetts, USA.ORCID https://orcid.org/0000-0002-9905-875X
Elif ÇakanRagon Institute of Mass General Brigham, MIT and Harvard, Cambridge, Massachusetts, USA.ORCID https://orcid.org/0000-0002-5606-2070
Anson HuiRagon Institute of Mass General Brigham, MIT and Harvard, Cambridge, Massachusetts, USA.

Funding

The importance of the IgG4 glycome in IgG4-related disease(s)U19AI110495 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI SHIV Subramaniam PILLAI · 2014 to 2026
$7.9M
Fondation LeducqMassachusetts Consortium on Pathogen ReadinessNIAID NIH HHS U19 AI110495NIH HHS AI110495NIH HHS AI1144295
6 · The paper itself

Abstract

This review will focus on some aspects of the biology of human peripheral B cells and how this biology might inform us as to why these cells are important therapeutic targets. Transitional B cells and the alterations in metabolism in transitional B cells as they mature may be relevant to the induction of B cell tolerance. The human extrafollicular B cell response and the activated B cell subsets that emerge both in extrafollicular responses as well as in germinal center responses will be discussed. The relatively transient nature of activated B cells in contrast to durable memory B cells will be considered and the review will also discuss how durable responses are generated both by extrafollicular responses as well as by germinal center responses.

Indexed as

B-Lymphocyte SubsetsAnimalsB-LymphocytesCell DifferentiationGerminal CenterHumansImmune ToleranceImmunologic MemoryLymphocyte Activation

Identifiers

PMID42740428
PMCPMC13575479

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.