Evidence map›Paper›PMID 42740418›Full record

ReviewMedical physics2026

Roadmap for the implementation of particle minibeam therapy.

Reem Ahmad, Oxana Actis, Adam H Aitkenhead, Richard A Amos, Niels Bassler, Catherine Burne, Pankaj Chaudhary, Gerd Datzmann, Umberto Deut, Fabio Di Martino and 23 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Reem AhmadRadiotherapy and Radiation Dosimetry Group, National Physical Laboratory, Teddington, UK.ORCID https://orcid.org/0000-0001-5529-9802
Oxana ActisCenter for Proton Therapy, Paul Scherrer Institute (PSI), Villigen, Switzerland.
Adam H AitkenheadChristie Medical Physics and Engineering, The Christie NHS Foundation Trust, Manchester Academic Health Science Centre (MAHSC), Manchester, UK.ORCID https://orcid.org/0000-0002-3478-5761
Richard A AmosDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.ORCID https://orcid.org/0000-0001-8266-772X
Niels BasslerDanish Centre for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-4160-1078
Catherine BurneSchool of Physics and Astronomy, University of Birmingham, Birmingham, UK.
Pankaj ChaudharyRadiotherapy and Radiation Dosimetry Group, National Physical Laboratory, Teddington, UK.ORCID https://orcid.org/0000-0002-0381-3635
Gerd DatzmannDatzmann Interact & Innovate, München, Germany.
Umberto DeutDepartment of Physics, Università di Torino, Torino, Italy.
Fabio Di MartinoUniversity-Hospital of Pisa, Pisa, Italy.
Rebecca HabgoodRadiotherapy and Radiation Dosimetry Group, National Physical Laboratory, Teddington, UK.ORCID https://orcid.org/0009-0003-6209-4604
Simon JollyDepartment of Physics and Astronomy, University College London, London, UK.
Emmanuel JouglarDepartment of Radiation Oncology, Institut Curie, PSL Research University - Paris and Orsay Protontherapy Center, Paris, France.
Eva KasandaAlbert Einstein Center for Fundamental Physics (AEC), Laboratory for High Energy Physics (LHEP), University of Bern, Bern, Switzerland.
Nigel LeeRadiotherapy and Radiation Dosimetry Group, National Physical Laboratory, Teddington, UK.ORCID https://orcid.org/0000-0002-0655-6873
Dominic LeiserCenter for Proton Therapy, Paul Scherrer Institute (PSI), Villigen, Switzerland.ORCID https://orcid.org/0000-0001-7535-1751
Xiangkun LiDeutsches Elektronen-Synchrotron, Zeuthen site, Zeuthen, Germany.ORCID https://orcid.org/0000-0002-5487-688X
Giuliana MilluzzoNational Institute for Nuclear Physics (INFN), Catania Division, Catania, Italy.ORCID https://orcid.org/0000-0001-5110-0659
Jessica NeubauerInstitute of Applied Physics and Measurement Technologies, Universität der Bundeswehr München, Neubiberg, Germany.ORCID https://orcid.org/0009-0002-0434-3660
Kelvin Ng Wei SiangDepartment of Radiotherapy, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0003-4315-4870
Hugo PalmansRadiotherapy and Radiation Dosimetry Group, National Physical Laboratory, Teddington, UK.ORCID https://orcid.org/0000-0002-0235-5118
Yolanda PrezadoNew Approaches in Radiotherapy Lab, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), University of Santiago de Compostela, A Coruña, Spain.ORCID https://orcid.org/0000-0001-5957-2327
Judith ReindlInstitute of Applied Physics and Measurement Technologies, Universität der Bundeswehr München, Neubiberg, Germany.ORCID https://orcid.org/0000-0002-3238-8586
Francesco RomanoNational Institute for Nuclear Physics (INFN), Catania Division, Catania, Italy.ORCID https://orcid.org/0000-0002-1865-6396
Loris RoncaliNew Approaches in Radiotherapy Lab, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), University of Santiago de Compostela, A Coruña, Spain.ORCID https://orcid.org/0009-0005-1505-5471
Aikaterini RoussetiInstitute of Applied Physics and Measurement Technologies, Universität der Bundeswehr München, Neubiberg, Germany.ORCID https://orcid.org/0009-0002-3851-7219
Thomas E SchmidDepartment of Radiooncology, TUM University Hospital, Munich, Germany.ORCID https://orcid.org/0000-0002-8894-8087
Ileana Silvestre PatalloRadiotherapy and Radiation Dosimetry Group, National Physical Laboratory, Teddington, UK.ORCID https://orcid.org/0000-0003-0467-3870
Frank StephanDeutsches Elektronen-Synchrotron, Zeuthen site, Zeuthen, Germany.ORCID https://orcid.org/0000-0001-5654-1250
Anna SubielRadiotherapy and Radiation Dosimetry Group, National Physical Laboratory, Teddington, UK.ORCID https://orcid.org/0000-0002-3467-4631
Edward TaylorDepartment of Oncology, University of Oxford, Oxford, UK.
Annalisa WalpenDivision of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.ORCID https://orcid.org/0009-0006-3987-3978
Samuel FlynnRadiotherapy and Radiation Dosimetry Group, National Physical Laboratory, Teddington, UK.ORCID https://orcid.org/0000-0001-6174-5434

Funding

Manchester Biomedical Research Centre NIHR203308National Institute for Nuclear Physics 2025-2027National Institute for Nuclear Physics INFN-CSN5National Measurements System Programmes UnitPRIN 2022 D.D. 104 February 2022 2022PLNN4FPRIN 2022 D.D. 104 February 2022 CUPI53C24002710006UK Research and Innovation MR/Y018761/1
6 · The paper itself

Abstract

Particle minibeam therapy (PMBT) has emerged as an advanced modality within spatially fractionated radiation therapy, using the physical properties of protons, ions, and electrons to achieve superior normal tissue sparing whilst preserving spatial dose distribution at depths that are unachievable in conventional kV or MV X-rays. As with any novel radiotherapy technique, successful translation into routine clinical practice requires robust evidence of efficacy, safety, and technical feasibility. This review presents a coordinated roadmap for the development and future implementation of PMBT, identifying the key challenges that must be addressed to enable safe and effective clinical implementation. This review highlights the interconnected nature of PMBT research and proposes the priority areas for future investigation, and the steps necessary to guide PMBT from experimental concept, towards clinical implementation. As most of the steps are relevant to all particle types, PMBT will be referred to in general, where specific particle types will be discussed where appropriate.

Indexed as

RadiotherapyHumansProton Therapyminibeam therapyparticle minibeam therapyPMBT workshop

Identifiers

PMID42740418
PMCPMC13575480

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.