Evidence map›Paper›PMID 42740413›Full record

ArticleChemical biology & drug design2026

Design, Synthesis, and Investigation of the Biological Activities of New Thiadiazole Derivatives With Anticancer Effects.

Yusuf Özkay, Enes Bal, Berkant Kurban, Derya Osmaniye, Begüm Nurpelin Sağlık Özkan, Zafer Asım Kaplancıklı

Abstract read
In one paragraph

Article in Chemical biology & drug design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yusuf ÖzkayDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Türkiye.
Enes Balİstanbul Süreyyapaşa Chest Diseases Training and Research Hospital, İstanbul, Türkiye.
Berkant KurbanDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Afyonkarahisar Health Sciences University, Afyonkarahisar, Türkiye.ORCID https://orcid.org/0000-0002-1595-3870
Derya OsmaniyeDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Türkiye.ORCID https://orcid.org/0000-0002-0499-436X
Begüm Nurpelin Sağlık ÖzkanDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Türkiye.ORCID https://orcid.org/0000-0002-0151-6266
Zafer Asım KaplancıklıDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Türkiye.ORCID https://orcid.org/0000-0003-2252-0923

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer is one of the most significant diseases in today's world. Hormone-dependent breast cancers constitute a significant portion of breast cancers. A series of thiadiazole derivative compounds have been designed to provide a rational alternative to aromatase inhibitors, which are actively used in related cancer treatments. The designed compounds were synthesized in three steps, and their structures were elucidated using

Indexed as

Antineoplastic AgentsDrug DesignThiadiazolesAromataseAromatase InhibitorsBreast NeoplasmsCell Line, TumorFemaleHumansMCF-7 CellsMolecular Docking SimulationMolecular Dynamics SimulationStructure-Activity RelationshipAntineoplastic AgentsAromataseAromatase InhibitorsThiadiazolesbreast cancermolecular dockingmolecular dynamicsthiadiazole

Identifiers

PMID42740413
PMCPMC13575461

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.