Evidence map›Paper›PMID 42739879›Full record

ArticleJournal of clinical medicine2026

Phenotype-Specific Pharmacogenetic Patterns of Methotrexate Neurotoxicity in Pediatric Acute Lymphoblastic Leukemia.

Javier Gómez-Román, Juan C Restrepo, Luz M González, Laura González-Rodríguez, Ángela Lacombe-Antoneli, Yolanda Gutiérrez-Martín, María Dolores de la Maya, Montserrat Mesegué, José Luis Dapena, Ana Carbone and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Javier Gómez-RománDepartment of Medical & Surgical Therapeutics, School of Medicine, University of Extremadura, 06006 Badajoz, Spain.ORCID 0009-0001-6144-1446
Juan C RestrepoCatalan Institute of Oncology, 43005 Tarragona, Spain.ORCID 0009-0003-8874-2622
Luz M GonzálezDepartment of Medical & Surgical Therapeutics, School of Medicine, University of Extremadura, 06006 Badajoz, Spain.
Laura González-RodríguezDepartment of Medical & Surgical Therapeutics, School of Medicine, University of Extremadura, 06006 Badajoz, Spain.ORCID 0009-0009-1648-0946
Ángela Lacombe-AntoneliLaboratorios Larrasa Human Personalized Medicine, 06170 Badajoz, Spain.
Yolanda Gutiérrez-MartínBioscience Applied Techniques Services, Servicio de Apoyo a la Investigación, University of Extremadura, 06006 Badajoz, Spain.ORCID 0000-0002-7552-1092
María Dolores de la MayaService of Hematology, Materno-Infantil Hospital, 06010 Badajoz, Spain.
Montserrat MeseguéService of Pediatric Hematology and Oncology, Sant Joan de Déu Barcelona Children's Hospital, 08950 Barcelona, Spain.
José Luis DapenaService of Pediatric Hematology and Oncology, Sant Joan de Déu Barcelona Children's Hospital, 08950 Barcelona, Spain.
Ana CarboneService of Pediatric Hematology and Oncology, Miguel Servet University Hospital, 50009 Zaragoza, Spain.
Berta González MartínezService of Pediatric Hematology and Oncology, La Paz University Hospital, 28046 Madrid, Spain.
Francisco Lendínez MolinosService of Pediatric Hematology and Oncology, Princesa Leonor Materno Infantil Hospital, 04009 Almería, Spain.
Antonio Molinés HonrubiaService of Pediatric Hematology and Oncology, Complejo Hospitalario Universitario Insular-Materno Infantil, 35016 Las Palmas de Gran Canaria, Spain.ORCID 0009-0004-0329-7652
Miriam Abós GarcíaService of Pediatric Hematology and Oncology, Donostia University Hospital, 20014 San Sebastián, Spain.
Marina García MorínService of Pediatric Hematology and Oncology, Gregorio Marañón General University Hospital, 28007 Madrid, Spain.
Samuel Navarro NogueraService of Pediatric Hematology and Oncology, Son Espases University Hospital, 07120 Palma, Spain.ORCID 0000-0003-1266-3373
María Sagaseta de IlurdozService of Pediatric Hematology and Oncology, Virgen del Camino Hospital, 31008 Pamplona, Spain.
Itziar AstigarragaService of Pediatric Hematology and Oncology, Cruces University Hospital, 48903 Barakaldo, Spain.
Maria Baro FernándezService of Pediatric Hematology and Oncology, 12 de Octubre University Hospital, 28041 Madrid, Spain.ORCID 0000-0002-2608-6055
Jaime Verdú AmorósService of Pediatric Hematology and Oncology, Hospital Clínico Universitario de Valencia, 46010 Valencia, Spain.ORCID 0000-0002-0900-0889
Alexandra RegueiroService of Pediatric Hematology and Oncology, University Clinical Hospital of Santiago de Compostela, 15706 Santiago de Compostela, Spain.ORCID 0000-0003-3156-4784
Manuel Ramírez OrellanaService of Pediatric Hematology and Oncology, Niño Jesús University Children's Hospital, 28009 Madrid, Spain.ORCID 0000-0003-0332-6973
José Luis Fuster SolerService of Pediatric Hematology and Oncology, Virgen de la Arrixaca University Clinical Hospital, 30120 Murcia, Spain.ORCID 0000-0002-4881-9440
Soledad González MuñizService of Pediatric Hematology and Oncology, Central University Hospital of Asturias, 33011 Oviedo, Spain.
Adela Cañete NietoService of Pediatric Hematology and Oncology, La Fe University and Polytechnic Hospital, 46026 Valencia, Spain.ORCID 0000-0002-5669-5097
Montserrat Torrent EspañolService of Pediatric Hematology and Oncology, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain.ORCID 0000-0003-1917-1056
Héctor González MéndezService of Pediatric Hematology and Oncology, University Hospital of the Canary Islands, 38320 San Cristóbal de La Laguna, Spain.
Jose M VagaceService of Hematology, Materno-Infantil Hospital, 06010 Badajoz, Spain.ORCID 0000-0001-8751-4319
Guillermo GervasiniDepartment of Medical & Surgical Therapeutics, School of Medicine, University of Extremadura, 06006 Badajoz, Spain.ORCID 0000-0002-0524-9767

Funding

Government of Extremadura GR24027Government of Extremadura IB18108
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

acute lymphoblastic leukemiamethotrexateneurotoxicitynext-generation sequencingpharmacogenomics

Identifiers

PMID42739879
PMCPMC13565789

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.