Evidence map›Paper›PMID 42739529›Full record

ReviewJournal of clinical medicine2026

Advanced Biological Therapies: Principles, Mechanisms and Medical Applications.

Rafal Brozek, Antonina Lorenz, Barbara Dorocka-Bobkowska, Maciej Kurpisz

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rafal BrozekDepartment of Prosthodontics and Geriatric Dentistry, Poznan University of Medical Sciences, 60-812 Poznan, Poland.ORCID 0000-0003-0917-9214
Antonina LorenzDepartment of Reproductive Biology and Stem Cells, Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.ORCID 0000-0003-4838-3621
Barbara Dorocka-BobkowskaDepartment of Prosthodontics and Geriatric Dentistry, Poznan University of Medical Sciences, 60-812 Poznan, Poland.ORCID 0000-0003-3659-7761
Maciej KurpiszDepartment of Reproductive Biology and Stem Cells, Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.ORCID 0000-0003-3275-3245

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biotherapeutics are medicinal agents derived from or related to naturally occurring molecules in the body and are designed to modulate specific immune targets. This review examines clinically established biologics and targeted small molecules that affect cytokine-driven transcriptional programs, principally JAK/STAT and canonical and non-canonical NF-κB signaling, across autoimmune, neoplastic, hematological, dermatological, and rheumatic diseases. Periodontitis is used as a translational model because dysbiotic mucosal inflammation, cytokine signaling, and osteoclastogenesis may also intersect with systemic autoimmunity. In particular,

Indexed as

BiopharmaceuticscytokinesJAK inhibitorsperiodontitisrheumatic diseasessignaling pathwaysSTAT inhibitors

Identifiers

PMID42739529
PMCPMC13566566

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.