Blood Eosinophil Subtype-Specific Protein Gene Expression and Eosinophil-Derived Serum Mediators in Allergic Asthma Patients After Bronchial Challenge with

Airidas Rimkunas, Andrius Januskevicius, Egle Vasyle, Jolita Palacionyte, Skaidrius Miliauskas, Kestutis Malakauskas

Abstract read

In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Airidas RimkunasLaboratory of Pulmonology, Department of Pulmonology, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania.ORCID 0000-0001-5418-3269

Andrius JanuskeviciusLaboratory of Pulmonology, Department of Pulmonology, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania.ORCID 0000-0002-8490-4212

Egle VasyleLaboratory of Pulmonology, Department of Pulmonology, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania.

Jolita PalacionyteDepartment of Pulmonology, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania.

Skaidrius MiliauskasDepartment of Pulmonology, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania.ORCID 0009-0002-6130-0712

Kestutis MalakauskasLaboratory of Pulmonology, Department of Pulmonology, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania.

Funding

Lithuanian University of Health Sciences

6 · The paper itself

Abstract

backgroundDifferences in gene expression between inflammatory-like (iEOS-like) and resident-like (rEOS-like) eosinophil subtypes, and in eosinophil-derived serum mediators, may reflect eosinophil functional activity and their potential role in the pathogenesis of allergic asthma (AA).

methodsTwenty-three patients with non-severe AA and thirteen healthy subjects (HS) were examined. AA patients underwent a bronchial allergen challenge (BAC) with

resultsBlood eosinophil subtypes from AA patients showed significantly higher expression of

conclusionsBAC induces a late-phase eosinophilic response in AA characterized by a partially eosinophil subtype-specific increase in gene expression and in circulating eosinophil-derived mediators. An increase in Gal10, observed at the

Indexed as

AsthmaBronchial Provocation TestsDermatophagoides pteronyssinusEosinophilsAdultAnimalsCase-Control StudiesEosinophil Cationic ProteinEosinophil-Derived NeurotoxinFemaleGalectinsGene Expression RegulationHumansMaleMiddle AgedEosinophil Cationic ProteinEosinophil-Derived NeurotoxinGalectinsallergic asthmabronchial allergen challengeeosinophil-derived mediatorseosinophil gene expressioneosinophilic inflammationeosinophil subtypes

Identifiers

PMID42738872

DOI10.3390/cells15171579

PMCPMC13565571

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.