Evidence map›Paper›PMID 42738849›Full record

ArticleCells2026

Stepwise Humanization of the Yeast TRAPP Core Enables Functional Analysis of TRAPP Variants.

Chelsea Abboud, Rozmehr Shokohi, Olivia Pape, Mahsa Mehranfar, Emma L Baple, Nadirah Damseh, Michael Sacher

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chelsea AbboudDepartment of Biology, Concordia University, Montreal, QC H4B 1R6, Canada.
Rozmehr ShokohiDepartment of Biology, Concordia University, Montreal, QC H4B 1R6, Canada.
Olivia PapeDepartment of Biology, Concordia University, Montreal, QC H4B 1R6, Canada.ORCID 0009-0008-0425-8259
Mahsa MehranfarDepartment of Biology, Concordia University, Montreal, QC H4B 1R6, Canada.
Emma L BapleDepartment of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter EX1 2LU, UK.ORCID 0000-0002-6637-3411
Nadirah DamsehDepartment of Pediatrics and Genetics, Makassed Hospital, Al-Quds Medical School, Jerusalem 19482, Israel.
Michael SacherDepartment of Biology, Concordia University, Montreal, QC H4B 1R6, Canada.ORCID 0000-0003-2926-5064

Funding

Concordia University N/ANatural Sciences and Engineering Research Council of Canada RGPIN-2020-04613
6 · The paper itself

Abstract

The Transport Protein Particle (TRAPP) complex is a highly conserved multi-subunit tethering complex that plays a critical role in membrane trafficking. Mutations in TRAPP complex subunits have been implicated in a growing spectrum of rare genetic disorders, yet the molecular mechanisms underlying variant pathogenicity often remain unclear. Here, we developed a humanized yeast platform to enable systematic functional characterization of TRAPP complex variants of uncertain significance. Using a stepwise gene replacement strategy in

Indexed as

Saccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsVesicular Transport ProteinsHumansModels, MolecularMutationProtein SubunitsProtein SubunitsSaccharomyces cerevisiae Proteinstransport protein particle, TRAPPVesicular Transport Proteinsgenome editinghumanizationTRAPPvariants of uncertain significanceyeast

Identifiers

PMID42738849
PMCPMC13564602

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.