Evidence map›Paper›PMID 42738834›Full record

ArticleCells2026

TWEAK/Fn14 Signaling Modulates Goblet Cell-Associated Mucin Responses in Mouse Small Intestinal Epithelial Organoids.

Shun Tamaki, Masayuki Kono, Sakura Arikawa, Yui Higashi, Tatsunori Maekawa, Yusuke Hara, Taizo Tsujimoto, Fumitaka Kawakami, Motoki Imai, Yoshifumi Kurosaki and 4 more

Abstract read
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In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shun TamakiDepartment of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University, Sagamihara 252-0373, Kanagawa, Japan.ORCID 0009-0009-7722-5623
Masayuki KonoDepartment of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University, Sagamihara 252-0373, Kanagawa, Japan.
Sakura ArikawaDepartment of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University, Sagamihara 252-0373, Kanagawa, Japan.
Yui HigashiDepartment of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University, Sagamihara 252-0373, Kanagawa, Japan.
Tatsunori MaekawaDepartment of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University, Sagamihara 252-0373, Kanagawa, Japan.ORCID 0000-0002-1214-9959
Yusuke HaraDepartment of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University, Sagamihara 252-0373, Kanagawa, Japan.
Taizo TsujimotoDepartment of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University, Sagamihara 252-0373, Kanagawa, Japan.
Fumitaka KawakamiDepartment of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University, Sagamihara 252-0373, Kanagawa, Japan.ORCID 0000-0002-8781-2516
Motoki ImaiRegenerative Medicine and Cell Design Research Facility, School of Allied Health Sciences, Kitasato University, Sagamihara 252-0373, Kanagawa, Japan.
Yoshifumi KurosakiDepartment of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University, Sagamihara 252-0373, Kanagawa, Japan.ORCID 0000-0003-3272-1470
Shokichi NaitoDepartment of Nephrology, Graduate School of Medical Sciences, Kitasato University, Sagamihara 252-0373, Kanagawa, Japan.
Naohito IshiiDepartment of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University, Sagamihara 252-0373, Kanagawa, Japan.
Takafumi IchikawaDepartment of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University, Sagamihara 252-0373, Kanagawa, Japan.
Rei KawashimaDepartment of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University, Sagamihara 252-0373, Kanagawa, Japan.ORCID 0009-0000-3242-1967

Funding

Kitasato University Grant-in-Aid for Research Projects, Grant No. 2025-47Kitasato University Grant-in-Aid for Research Projects, Grant No. 2026-15Kitasato University Research Grant for Young Researchers, Grant No. 2023-4023
6 · The paper itself

Abstract

Intestinal barrier dysfunction and mucus layer abnormalities are central features of inflammatory bowel disease, yet the epithelial mechanisms regulating goblet cell function remain incompletely understood. The TWEAK/Fn14 pathway is involved in intestinal inflammation, but its role in small intestinal epithelial responses, particularly in goblet cells, has not been fully clarified. In this study, we investigated TWEAK/Fn14 signaling using mouse small intestinal epithelial organoids. Fn14 was expressed in MUC2-positive cells in intestinal tissue, with staining preferentially observed toward the mucin-facing region. Fn14 staining was also observed in small intestinal epithelial organoids. TWEAK stimulation increased

Indexed as

Cytokine TWEAKGoblet CellsIntestine, SmallMucin-2MucinsOrganoidsSignal TransductionTWEAK ReceptorAnimalsIntestinal MucosaMiceMice, Inbred C57BLRNA, MessengerTumor Necrosis Factor-alphaCytokine TWEAKMuc2 protein, mouseMucin-2MucinsRNA, MessengerTnfrsf12a protein, mouseTnfsf12 protein, mouseTumor Necrosis Factor-alphaTWEAK Receptorgoblet cellsintestinal inflammationMUC2mucinmucus barriersmall intestinal epithelial organoidsTNFTWEAK/Fn14 signaling

Identifiers

PMID42738834
PMCPMC13565329

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.