Evidence map›Paper›PMID 42738800›Full record

ArticleCells2026

Mechanical Suppression of Sonic Hedgehog Signaling by Nucleus Pulposus Cells Underlies Early Disc Degeneration in Mouse.

Sohrab Virk, Veeraj Shah, Vikrant Piprode, Claire Marie Kemp, Harshith Alluri, Kathleen F Vincent, Ravi Krishnan, Justin Hong, Todd J Albert, Chitra L Dahia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sohrab VirkSpine Service, Hospital for Special Surgery, New York, NY 10021, USA.
Veeraj ShahOrthopedic Soft Tissue Research Program, Hospital for Special Surgery, New York, NY 10021, USA.ORCID 0009-0005-1935-0566
Vikrant PiprodeOrthopedic Soft Tissue Research Program, Hospital for Special Surgery, New York, NY 10021, USA.ORCID 0000-0003-1753-8301
Claire Marie KempOrthopedic Soft Tissue Research Program, Hospital for Special Surgery, New York, NY 10021, USA.
Harshith AlluriOrthopedic Soft Tissue Research Program, Hospital for Special Surgery, New York, NY 10021, USA.
Kathleen F VincentOrthopedic Soft Tissue Research Program, Hospital for Special Surgery, New York, NY 10021, USA.ORCID 0000-0001-6098-9998
Ravi KrishnanOrthopedic Soft Tissue Research Program, Hospital for Special Surgery, New York, NY 10021, USA.
Justin HongOrthopedic Soft Tissue Research Program, Hospital for Special Surgery, New York, NY 10021, USA.ORCID 0009-0003-4025-5980
Todd J AlbertSpine Service, Hospital for Special Surgery, New York, NY 10021, USA.
Chitra L DahiaOrthopedic Soft Tissue Research Program, Hospital for Special Surgery, New York, NY 10021, USA.ORCID 0000-0003-3683-9791

Funding

Role of Developmental Signaling Pathways in Maintenance of Spinal DiscsR01AG070079 · NIA · HOSPITAL FOR SPECIAL SURGERY · PI Chitra L Dahia · 2021 to 2026
$3.3M
Role of Shh/Brachyury axis in the maintenance of the postnatal intervertebral discR01AR077145 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI DAHIA, CHITRA L · 2021 to 2025
$3.0M
Fluorescent StereomicroscopeS10OD026763 · OD · HOSPITAL FOR SPECIAL SURGERY · PI DAHIA, CHITRA L · 2019 to 2019
$60k
NIAMS NIH HHS R01 AR077145NIA NIH HHS R01 AG070079NIA NIH HHS R01AG070079NIH HHS S10 OD026763NIH HHS S10OD026763
6 · The paper itself

Abstract

Sonic hedgehog (SHH) expression by nucleus pulposus (NP) cells is important for intervertebral disc development and maintenance. The lumbosacral disc, the most immobile region of the spine, lies adjacent to the sacrum and is most vulnerable to degeneration. We hypothesized that a lack of mobility represses SHH expression by NP cells, leading to degenerative changes in the intervertebral disc. To test this hypothesis, we employed a

Indexed as

Hedgehog ProteinsIntervertebral Disc DegenerationNucleus PulposusSignal TransductionAnimalsIntervertebral DiscIon ChannelsMechanotransduction, CellularMiceZinc Finger Protein GLI1Hedgehog ProteinsIon ChannelsPiezo1 protein, mouseShh protein, mouseZinc Finger Protein GLI1disc degenerationimmobilitymechanotransductionnucleus pulposusPiezo1sonic hedgehogstatic compressiontail-loop model

Identifiers

PMID42738800
PMCPMC13565538

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.