Hexafluoroisopropanol Mediated Ring-Opening Reactions of Epoxides with Indoles Under Catalyst-Free Conditions.

Yangmin Ma, Ding Ma, Zhichao Wang, Murong Zhan, Qian Jiao, Sen Yang

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yangmin MaKey Laboratory of Chemical Additives, China National Light Industry, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.

Ding MaKey Laboratory of Chemical Additives, China National Light Industry, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.

Zhichao WangKey Laboratory of Chemical Additives, China National Light Industry, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.

Murong ZhanKey Laboratory of Chemical Additives, China National Light Industry, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.

Qian JiaoKey Laboratory of Chemical Additives, China National Light Industry, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.

Sen YangKey Laboratory of Chemical Additives, China National Light Industry, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.

Funding

National Natural Science Foundation of China 22178205

6 · The paper itself

Abstract

An efficient, catalyst-free, and room-temperature protocol has been developed for the ring-opening reactions of ring cyclic ethers with indoles in Hexafluoroisopropanol (HFIP). Under these mild conditions, a diverse range of indoles smoothly reacted with oxirane within 6 h, affording the corresponding C3-alkylated indoles in good-to-excellent yields. Notably, this method also shows promising reactivity toward four-membered oxetanes. Furthermore, stereospecific investigations employing enantiopure (R)-styrene oxide afforded the corresponding products with high enantiomeric excess, suggesting an S

Indexed as

catalyst-freeepoxidesHFIPindole derivativesring-opening

Identifiers

PMID42738768

DOI10.3390/molecules31173108

PMCPMC13567142

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.