ArticleMolecules (Basel, Switzerland)2026
Cytotoxic Triterpenes from Argan Pulp (
Asma El Kaourat, Badr Eddine Kartah, Mohamed El Fadili, Noura Bentarhlia, Hamza Tachallait, Yassine Jaouhari, Matteo Bordiga, Zineb Ourradi, Younes Zaid, Zoubida Charrouf and 1 more
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In one paragraphArticle in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
11 authors.
Asma El KaouratLaboratory of Plant Chemistry, Organic and Bioorganic Synthesis, Faculty of Sciences, Mohammed V University in Rabat, Agdal, Rabat 10000, Morocco.
Badr Eddine KartahLaboratory of Plant Chemistry, Organic and Bioorganic Synthesis, Faculty of Sciences, Mohammed V University in Rabat, Agdal, Rabat 10000, Morocco.
Mohamed El FadiliLaboratoire d'Ingénierie, Modélisation et Analyse des Systèmes (LIMAS Laboratory), Chemistry Department, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, Fez 30000, Morocco.ORCID 0000-0002-2211-3298 Noura BentarhliaLaboratory of Plant Chemistry, Organic and Bioorganic Synthesis, Faculty of Sciences, Mohammed V University in Rabat, Agdal, Rabat 10000, Morocco.
Hamza TachallaitDepartment of Chemical and Biochemical Sciences-Green Process Engineering (CBS-GPE), Mohammed VI Polytechnic University (UM6P), Ben Guerir 43150, Morocco.ORCID 0000-0002-4281-3777 Yassine JaouhariDepartment of Pharmaceutical Science, Università degli Studi del Piemonte Orientale "A. Avogadro", Largo Donegani 2, 28100 Novara, Italy.ORCID 0009-0009-5686-7993 Matteo BordigaDepartment of Pharmaceutical Science, Università degli Studi del Piemonte Orientale "A. Avogadro", Largo Donegani 2, 28100 Novara, Italy.ORCID 0000-0001-6587-9843 Zineb OurradiMaterials, Nanotechnologies and Environment Laboratory, Department of Biology, Faculty of Sciences, Mohammed V University in Rabat, Rabat 10000, Morocco.ORCID 0009-0007-9341-3435 Younes ZaidMaterials, Nanotechnologies and Environment Laboratory, Department of Biology, Faculty of Sciences, Mohammed V University in Rabat, Rabat 10000, Morocco.ORCID 0000-0001-8750-9106 Zoubida CharroufLaboratory of Plant Chemistry, Organic and Bioorganic Synthesis, Faculty of Sciences, Mohammed V University in Rabat, Agdal, Rabat 10000, Morocco.ORCID 0000-0002-6938-7747 Hanae El MonfaloutiLaboratory of Plant Chemistry, Organic and Bioorganic Synthesis, Faculty of Sciences, Mohammed V University in Rabat, Agdal, Rabat 10000, Morocco.ORCID 0000-0002-5192-9034 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
This study focuses on the isolation, characterization, and evaluation of cytotoxicity of triterpenes extracted from argan pulp. The unsaponifiable lipids extracted from argan pulp are separated into five fractions, two of which are triterpene fractions F2 (composed of α-amyrin, β-amyrin, lupeol, ψ-taraxasterol, taraxasterol) and F4 (erythrodiol). The extraction process utilized solvent-based methods followed by purification through column chromatography. Structural elucidation was carried out using GC-MS and NMR techniques. The cytotoxic activity of the fractions was evaluated against HepG2, MCF-7, and HeLa cell lines. Fraction F4 exhibited IC
Indexed as
Antineoplastic Agents, PhytogenicPlant ExtractsSapotaceaeTriterpenesApoptosisCell Line, TumorHeLa CellsHep G2 CellsHumansLupanesMCF-7 CellsMolecular Docking SimulationOleanolic AcidAntineoplastic Agents, PhytogenicLupanesOleanolic AcidPlant ExtractsTriterpenesamyrinargan pulpby-producterythrodiolpentacyclic triterpenessustainability
Identifiers
PMID42738671
PMCPMC13567469
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