ArticleMolecules (Basel, Switzerland)2026
5-Nitrothiazol-Clofibric Acid Analogs as Potent Agents Against Nitazoxanide-Resistant
Beatriz Hernández-Ochoa, Blanca Colin-Lozano, Gabriel Navarrete-Vázquez, Sergio Enríquez-Flores, Ignacio De la Mora-De la Mora, Verónica Pérez de la Cruz, Roberto Arreguin-Espinosa, Rosa Angélica Castillo-Rodríguez, José Antonio Velázquez-Aragón, Julieta Griselda Mendoza-Torreblanca and 5 more
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
15 authors.
Beatriz Hernández-OchoaLaboratorio de Investigación en Ciencias Ómicas y Epidemiología Microbiana, Hospital Infantil de México Federico Gómez, Secretaría de Salud, Mexico City 06720, Mexico.
Gabriel Navarrete-VázquezFacultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca 62209, Morelos, Mexico.ORCID 0000-0001-5344-4762 Sergio Enríquez-FloresLaboratorio de Biomoléculas y Salud Infantil, Instituto Nacional de Pediatría, Secretaría de Salud, Mexico City 04530, Mexico.ORCID 0000-0003-2058-5707 Ignacio De la Mora-De la MoraLaboratorio de Biomoléculas y Salud Infantil, Instituto Nacional de Pediatría, Secretaría de Salud, Mexico City 04530, Mexico.ORCID 0000-0002-5654-8089 Verónica Pérez de la CruzNeurobiochemistry and Behavior Laboratory, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", Mexico City 14269, Mexico.ORCID 0000-0002-1451-8754 Roberto Arreguin-EspinosaDepartamento de Química de Biomacromoléculas, Instituto de Química, Universidad Nacional Autónoma de México, México City 04510, Mexico.ORCID 0000-0002-4611-4770 Rosa Angélica Castillo-RodríguezCentro de Investigación en Ciencia Aplicada y Tecnología Avanzada (CICATA) Unidad Morelos, Instituto Politécnico Nacional, Xochitepec 62790, Morelos, Mexico.ORCID 0000-0003-4117-6689 José Antonio Velázquez-AragónLaboratorio de Oncología Experimental, Instituto Nacional de Pediatría, Mexico City 04530, Mexico.ORCID 0000-0002-3617-8148 Julieta Griselda Mendoza-TorreblancaLaboratorio de Neurociencias, Instituto Nacional de Pediatría, Secretaría de Salud, Mexico City 04530, Mexico.
Noemí Cárdenas-RodríguezLaboratorio de Neurociencias, Instituto Nacional de Pediatría, Secretaría de Salud, Mexico City 04530, Mexico.ORCID 0000-0002-6580-3440 Daniel Ortega-CuellarLaboratorio de Nutrición Experimental, Instituto Nacional de Pediatría, Secretaría de Salud, Mexico City 04530, Mexico.
Cindy BandalaLaboratorio de Neurociencia Traslacional, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, Mexico.ORCID 0000-0002-7414-2621 Abraham Vidal-LimonRed de Estudios Moleculares Avanzados, Clúster Científico y Tecnológico BioMimic®, Instituto de Ecología A.C. (INECOL), Xalapa 91073, Veracruz, Mexico.ORCID 0000-0001-5674-7881 Saúl Gómez-ManzoLaboratorio de Bioquímica Genética, Instituto Nacional de Pediatría, Secretaría de Salud, Mexico City 04530, Mexico.ORCID 0000-0003-2095-9182 Funding
Hospital Infantil de México Federico Gómez HIM/2019/036 SSA.1595Instituto Nacional de Pediatria INP 020/2025National Supercomputing Center-IPICYT TKII-AMVL001Secretaría de Ciencia, Humanidades, Tecnología e Innovación CF-2023-I-811
6 · The paper itselfAbstract
Giardiasis remains a significant global health issue, and its treatment is increasingly hampered by the emergence of drug resistance and cross-resistance between nitroimidazoles and nitazoxanide. In this study, we evaluated the in vitro antigiardial activity, cytotoxicity, and potential mechanisms of action of seven structural analogs (CLB 1-7) derived from a hybrid structure combining nitazoxanide and clofibric acid. Among them, compounds CLB-3 and CLB-5 emerged as the most potent candidates, demonstrating exceptional efficacy against a nitazoxanide-resistant (NTZr) strain of
Indexed as
Antiprotozoal AgentsDrug ResistanceGiardia lambliaGlycolysisThiazolesCaco-2 CellsHumansMolecular Docking SimulationMolecular Dynamics SimulationNitro CompoundsAntiprotozoal AgentsnitazoxanideNitro CompoundsThiazoles5-nitrothiazoleantigiardial activitygene expressionGiardia lambliamolecular dockingmolecular dynamics simulations
Identifiers
PMID42738643
PMCPMC13567709
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