Evidence map›Paper›PMID 42738421›Full record

ArticleAnimals : an open access journal from MDPI2026

Integrated Transcriptomic and Proteomic Analyses Reveal the Effects and Mechanisms of Glycyrrhiza Polysaccharides in Alleviating Immune Stress in Broilers.

Shuyan Wu, Boyi Dong, Dongying Weng, Jiaqi Chen, Hongzhu Jin, Xinrui Lin, Weize Qin, Shuyi Li, Haidong Du, Tiyu Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shuyan WuCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China.ORCID 0009-0007-9164-589X
Boyi DongCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China.
Dongying WengCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China.
Jiaqi ChenCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China.
Hongzhu JinCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China.
Xinrui LinCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China.
Weize QinCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China.
Shuyi LiCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China.
Haidong DuCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China.ORCID 0000-0002-8905-3947
Tiyu LiCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China.ORCID 0009-0001-1742-6708

Funding

Fundamental Research Funds for the Universities Directly under the Inner Mongolia Autonomous Region GXKY23Z003Key R&D and Achievement Transformation Program of Inner Mongolia (Northeast Revitali-zation) 2025YFDZ0099Natural Science Foundation of Inner Mongolia Autonomous Region 2025MS03130
6 · The paper itself

Abstract

Immune stress under intensive high density production conditions impairs broiler health and performance, highlighting the need for effective nutritional strategies. This study established an immune stress model by intraperitoneal lipopolysaccharide (LPS) injection to investigate the mechanism by which Glycyrrhiza polysaccharides (GPs) alleviate LPS-induced immune stress. A total of 240 AA broilers were randomly assigned to four groups: control (CON), GP, LPS, and GP + LPS, with six replicates per group and ten birds per replicate. During the stress phase (28 d), LPS challenge increased serum ACTH and CORT concentrations and altered several immune-related parameters; whereas, GP supplementation improved ileal morphology and reduced serum IL-1β, NF-κB, and TNF-α concentrations. Significant GP × LPS interactions were observed for IL-4, IgA, IgG, and iNOS. During the recovery phase (35 d), GP supplementation increased serum IgA and decreased iNOS, while significant GP × LPS interactions were detected for IL-1β, NF-κB, and sCD4. Notably, GP attenuated the LPS-associated increase in NF-κB. Integrated multi-omics analysis indicated coordinated regulation at transcriptional and proteomic levels. GP upregulated

Indexed as

broilerGlycyrrhiza polysaccharidesimmune stresssignaling pathways

Identifiers

PMID42738421
PMCPMC13564342

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.