Evidence map›Paper›PMID 42738349›Full record

ArticleCancers2026

High Histological Skeletonization as a Measure of Heterogeneity Is Associated with Poor Overall Survival and Death Within 2 Years of Diffuse Large B-Cell Lymphoma.

Joaquim Carreras, Yara Yukie Kikuti, Shunsuke Nagase, Giovanna Roncador, Haruka Ikoma, Atsushi Ito, Makoto Orita, Sakura Tomita, Yuki Tanigaki, Akihisa Ueno and 3 more

Abstract read
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In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Joaquim CarrerasDepartment of Pathology, School of Medicine, Tokai University, 143 Shimokasuya, Isehara 259-1193, Japan.ORCID 0000-0002-6129-8299
Yara Yukie KikutiDepartment of Pathology, School of Medicine, Tokai University, 143 Shimokasuya, Isehara 259-1193, Japan.
Shunsuke NagaseDepartment of Pathology, School of Medicine, Tokai University, 143 Shimokasuya, Isehara 259-1193, Japan.ORCID 0000-0002-6130-3879
Giovanna RoncadorMonoclonal Antibodies Unit, Spanish National Cancer Research Center (CNIO), Centro Nacional de Investigaciones Oncologicas, C/Melchor Fernandez Almagro, 3, 28029 Madrid, Spain.ORCID 0000-0002-9807-2875
Haruka IkomaDepartment of Pathology, School of Medicine, Tokai University, 143 Shimokasuya, Isehara 259-1193, Japan.
Atsushi ItoDepartment of Pathology, School of Medicine, Tokai University, 143 Shimokasuya, Isehara 259-1193, Japan.ORCID 0000-0003-3482-2742
Makoto OritaDepartment of Pathology, School of Medicine, Tokai University, 143 Shimokasuya, Isehara 259-1193, Japan.
Sakura TomitaDepartment of Pathology, School of Medicine, Tokai University, 143 Shimokasuya, Isehara 259-1193, Japan.
Yuki TanigakiDepartment of Pathology, School of Medicine, Tokai University, 143 Shimokasuya, Isehara 259-1193, Japan.ORCID 0009-0005-0542-2549
Akihisa UenoDepartment of Pathology, School of Medicine, Tokai University, 143 Shimokasuya, Isehara 259-1193, Japan.ORCID 0000-0001-9428-4128
Yusuke KondoDepartment of Pathology, School of Medicine, Tokai University, 143 Shimokasuya, Isehara 259-1193, Japan.
Naoya NakamuraDepartment of Pathology, School of Medicine, Tokai University, 143 Shimokasuya, Isehara 259-1193, Japan.
Yohei MasugiDepartment of Pathology, School of Medicine, Tokai University, 143 Shimokasuya, Isehara 259-1193, Japan.

Funding

Ministry of Education, Culture, Sports, Science and Technology KAKENHI, JSPS grant number 25K10272 23K06454 18K15100 15K19061 24590430
6 · The paper itself

Abstract

backgroundDiffuse large B-cell lymphoma (DLBCL) is an aggressive lymphoma that is histologically and clinically heterogeneous. Skeletonization is a computer vision technique used in image description, segmentation, and pattern recognition.

objectivesThis retrospective observational study analyzed the 2D-topological heterogeneity of DLBCL.

methodsA series of 153 patients, including 110 patients with DLBCL and 43 patients with reactive lymphoid tissue, were analyzed by skeleton analysis using hematoxylin and eosin (H&E) digitized images. The skeletonization variable was correlated with several clinicopathological characteristics of the patients, including cell of origin Hans' classifier and Lymph2Cx assay, MYC and BCL2 rearrangement by FISH, immunohistochemistry of BCL2, CASP8, cCASP3, CD163, CDK6, cPARP, CSF1R, E2F1, ISY1, Ki69, LMO2, MDM2, MYC, MYO, TNFAIP8, PD-L1, and p53, and gene expression using a pancancer immune profiling panel.

resultsIn comparison with reactive tissue, DLBCL was characterized by lower skeletonization: 5665.20 ± 1012.82 vs. 6341.16 ± 548.23, respectively (

conclusionsDLBCL is characterized by lower skeletonization than reactive lymphoid tissue. In DLBCL, high skeletonization is associated with poor prognosis and enrichment of immuno-oncology markers.

Indexed as

computer visiondiffusediffuse large B-cell lymphomaentropygene expressionimmuno-oncologylarge B-Celllymphomaprognosisskeletonizationsurvival

Identifiers

PMID42738349
PMCPMC13564704

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.