ArticleCancers2026
Effect of Anesthesia Type on Clinically Significant Prostate Cancer Detection in Transperineal MRI-Targeted Biopsy.
Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
Abstract
BACKGROUND/
objectivesThe transperineal approach is the recommended standard for prostate biopsy. We aimed to determine whether anesthesia type-local anesthesia (LA) versus general anesthesia (GA)-independently influences clinically significant prostate cancer (csPCa) detection in transperineal magnetic resonance imaging (MRI)-targeted biopsy and to evaluate its impact on biopsy-prostatectomy pathological concordance.
methodsThis single-center retrospective study included biopsy-naive men undergoing cognitive-fusion transperineal prostate biopsy under LA or GA. Propensity score matching (1:1) was performed on age, prostate-specific antigen, PI-RADS score, and prostate volume. The primary outcome was csPCa detection (ISUP Grade Group ≥ 2) on combined systematic and targeted biopsy. Secondary outcomes included overall and high-grade cancer detection and biopsy-prostatectomy pathological concordance.
resultsAfter matching, 220 pairs (440 patients) were analyzed. csPCa detection on combined biopsy did not differ between LA and GA (40.5% vs. 37.7%,
conclusionsAnesthesia type was not significantly associated with csPCa detection in transperineal cognitive-fusion biopsy, and pathological concordance was similar between LA and GA. These findings support the feasibility of LA transperineal biopsy, although the confidence intervals do not establish formal equivalence between the two approaches.
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