Evidence map›Paper›PMID 42738331›Full record

ArticleCancers2026

Comprehensive Genomic Profiling Reveals the Mutational Spectrum and Clinical Significance of BRCA1/2 and Other Cancer-Susceptibility Genes in Breast Cancer Patients from Southern Tunisia.

Nihel Ammous-Boukhris, Rania Abdelmaksoud-Dammak, Wala Ben Kridis, Dorra Ben-Ayed-Guerfali, Souhir Guidara, Ameni Feki, Hassen Kamoun, Afef Khanfir, Jamel Daoud, Gérard-Hubert Lizard and 2 more

Abstract read
In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nihel Ammous-BoukhrisCenter of Biotechnology of Sfax, Laboratory of Molecular Biotechnology of Eukaryotes, University of Sfax, Sfax 3018, Tunisia.ORCID 0000-0002-5744-0328
Rania Abdelmaksoud-DammakCenter of Biotechnology of Sfax, Laboratory of Molecular Biotechnology of Eukaryotes, University of Sfax, Sfax 3018, Tunisia.ORCID 0009-0009-9777-7222
Wala Ben KridisDepartment of Medical Oncology, Habib Bourguiba Hospital, Sfax 3018, Tunisia.ORCID 0000-0002-4956-9551
Dorra Ben-Ayed-GuerfaliCenter of Biotechnology of Sfax, Laboratory of Molecular Biotechnology of Eukaryotes, University of Sfax, Sfax 3018, Tunisia.
Souhir GuidaraDepartment of Genetics, Hedi Chaker Hospital, Sfax 3018, Tunisia.ORCID 0000-0001-5976-2657
Ameni FekiDepartment of Medical Oncology, Habib Bourguiba Hospital, Sfax 3018, Tunisia.
Hassen KamounDepartment of Genetics, Hedi Chaker Hospital, Sfax 3018, Tunisia.
Afef KhanfirDepartment of Medical Oncology, Habib Bourguiba Hospital, Sfax 3018, Tunisia.
Jamel DaoudDepartment of Radiotherapy, Habib Bourguiba Hospital, Sfax 3018, Tunisia.
Gérard-Hubert LizardLaboratoire Interdisciplinaire Carnot de Bourgogne ICB UMR 6303, University of Bourgogne Europe/CNRS/Inserm, 21000 Dijon, France.ORCID 0000-0001-6330-0172
Ali GargouriCenter of Biotechnology of Sfax, Laboratory of Molecular Biotechnology of Eukaryotes, University of Sfax, Sfax 3018, Tunisia.ORCID 0000-0001-5009-9000
Raja Mokdad-GargouriCenter of Biotechnology of Sfax, Laboratory of Molecular Biotechnology of Eukaryotes, University of Sfax, Sfax 3018, Tunisia.ORCID 0000-0003-1319-0061

Funding

Tunisian Ministery of Higher education and research LR19CBS02
6 · The paper itself

Abstract

BACKGROUND/

objectivesThis study aims to investigate the mutational spectrum of

resultsAmong the 165 patients included, pathogenic or likely pathogenic variants (P/LPVs) in

conclusionsOur findings provide novel insights into the genetic landscape of breast cancer in southern Tunisia, highlighting the clinical relevance of

Indexed as

BRCA1BRCA2breast cancerpathogenic/likely pathogenic varianttargeted next-generation sequencingvariant of unknown significance

Identifiers

PMID42738331
PMCPMC13565643

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.