ArticleCancers2026
Mitoxyperilysis Drives Immunosuppressive Tumor Microenvironment Remodeling and Hepatocellular Carcinoma Progression via ANXA1-Mediated Macrophage M2 Polarization.
Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMitoxyperilysis is a recently described form of regulated cell death, but its clinical and immunological relevance in hepatocellular carcinoma (HCC) remains unclear. This study investigated the prognostic significance of mitoxyperilysis-related transcriptional activity and its role in remodeling the tumor immune microenvironment.
methodsA Mitoxyperilysis Score was generated by single-sample gene set enrichment analysis. Prognostic associations were evaluated using Kaplan-Meier analysis, multivariable Cox regression, independent cohort validation, and random-effects meta-analysis. Immune infiltration and cell-cell communication were examined using bulk transcriptomic and single-cell RNA-sequencing data. The functional role of ANXA1 was assessed by ELISA, Western blotting, macrophage co-culture, immunofluorescence, flow cytometry,
resultsHigh Mitoxyperilysis Scores were associated with shorter overall survival in TCGA-LIHC (log-rank
conclusionsMitoxyperilysis-related transcriptional activity is associated with adverse survival and an M2-enriched immunosuppressive microenvironment in HCC. ANXA1 is an important, although probably not exclusive, mediator of this process and may represent a potential therapeutic target.
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