ArticleBiology2026
The Erk/CREB Signaling Axis Mediates G-CSF-Promoted G-MDSC Survival in the Peripheral Blood of Melanoma-Bearing Mice.
Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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8 authors.
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Abstract
Myeloid-derived suppressor cells (MDSCs) are heterogeneous cell populations that promote tumor development by inhibiting innate and adaptive immunity. Under physiological conditions, neutrophils have a short survival time in vivo. However, G-MDSCs accumulate abnormally in most tumor hosts, and the mechanisms underlying G-MDSC persistence remain to be clarified. This study utilized flow cytometric analysis and in vivo assays to elucidate these mechanisms. It was observed that the apoptosis of G-MDSCs in the peripheral blood of mice was reduced under tumor conditions, whereas an increase in granulocyte colony-stimulating factor (G-CSF) promoted the survival of G-MDSCs. Furthermore, G-CSF reduced the apoptosis of G-MDSCs by activating the Erk/CREB pathway. Thus, inhibition of G-CSF/Erk/CREB signaling may promote the apoptosis of G-MDSCs and shorten their persistence under tumor conditions, as well as attenuate tumor progression.
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