ReviewBiology2026
Age and Sex as Moderators of Sleep Architecture in Schizophrenia, Bipolar Disorder, and Unipolar Depression: A Case-Control Polysomnographic Systematic Review and Meta-Regression.
Review in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
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Abstract
Sleep architecture alterations have been shown in major psychiatric disorders, but the contribution of demographic factors to between-study heterogeneity remains insufficiently characterized. This study reports a transdiagnostic systematic review and meta-regression of case-control polysomnographic studies comparing schizophrenia, bipolar disorder, and unipolar depression with healthy controls. The factors age and sex as possible moderators across harmonized case-control polysomnographic studies have been analyzed. Eligible studies reported diagnostic criteria, treatment status, age, and sex. Because the UD literature encompassed developmentally distinct populations, pediatric/adolescent and adult studies were analyzed separately. Standardized mean differences were synthesized using random-effects models with REML estimation. Univariable mixed-effects meta-regressions assessed study-level mean age and sex composition as moderators within each diagnostic group. Study-level mean age and sex composition significantly moderated delta sleep effect sizes in drug-naive schizophrenia, while study-level mean age significantly moderated REM time in drug-free schizophrenia. In bipolar disorder, study-level mean age moderated REM sleep time effect sizes during mania, whereas sex composition moderated delta sleep and REM density effect sizes. In UD, study-level mean age moderated total sleep time, and sex composition moderated wake after sleep onset only in pediatric/adolescent studies, whereas no significant moderation was observed in adult samples. No significant moderator effects were identified during bipolar depression. Overall, demographic composition explained only a modest proportion of between-study heterogeneity. Interpretation is limited by the ecological nature of study-level meta-regression and residual study heterogeneity.
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