Evidence map›Paper›PMID 42737891›Full record

ArticleBiology2026

N-Acetyl-L-Cysteine Promotes Porcine Oocyte In Vitro Maturation and Subsequent Embryonic Development by Regulating Oxidative Stress.

Li Wang, Kelin Song, Qiuyu Meng, Feng Yang, Xuelei Han, Ruimin Qiao, Kejun Wang, Jun Bai, Tengfei Wang, Xiuling Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Li WangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Kelin SongCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Qiuyu MengCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Feng YangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.ORCID 0000-0003-1915-6008
Xuelei HanCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Ruimin QiaoCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Kejun WangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.ORCID 0000-0003-4337-980X
Jun BaiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Tengfei WangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Xiuling LiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.ORCID 0000-0003-1175-2622
Tong YuCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.ORCID 0000-0003-0434-3126
Xinjian LiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.ORCID 0000-0003-2546-0145

Funding

National Key R&D Program of China 2023YFF0724704Pig Industry Technology System Innovation Team Project of Henan Province HARS-22-12-G4
6 · The paper itself

Abstract

In vitro maturation (IVM) of oocytes is a critical initial step in mammalian in vitro production (IVP), and its quality directly influences the developmental competence of subsequent embryos. Oxidative stress is a major constraint on oocyte quality, which can be mitigated by exogenous antioxidants. In this study, porcine oocytes were matured in IVM medium supplemented with the antioxidant N-acetyl-L-cysteine (NAC; 0, 0.5, 1.5, and 4 mM) to evaluate its effects on maturation rate, antioxidant capacity, mitochondrial function, vitrification-warming survival rate, post-warming ROS levels, and early embryonic developmental rate. To elucidate the molecular mechanisms underlying the effects of NAC on porcine oocyte maturation, we conducted single-cell transcriptome sequencing. The results showed that, versus the control, 1.5 mM NAC substantially enhanced the IVM rate (

Indexed as

IVF embryonic developmentmitochondrial functionNACporcine oocyte qualityrelieved oxidative stress

Identifiers

PMID42737891
PMCPMC13564785

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.